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Systemic mastocytosis associated with essential thrombocythemia.
MedLine Citation:
PMID:  22395523     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Mastocytosis comprises a spectrum of disorders characterized by abnormal growth of mast cells (MS). Four entities are recognizable according to WHO classification. Association of systemic mastocytosis (SM) with a chronic myeloproliferative neoplasia (SM-AHNMD) is the second frequently category. Published descriptions of the clinicopathologic features of SM-AHNMD are largely limited to individual case reports. We present the case of a 41-year-old woman with thrombocytosis and mild splenomegaly. Clinical suspicion was of chronic myeloproliferative neoplasia (CMN). Bone marrow trephine biopsy examination (histology and immunohistochemistry for CD117 and CD25) revealed a SM associated with CMN, essential thrombocythemia (ET) type. The JAK2 V617F (for CMN) was detected but KIT ÷ Asp816Val (reported in ˜80% of SM) was absent. We discussed the particularity of the cases correlated with a review of the literature.
Authors:
Camelia Dobrea; M Ciochinaru; Amelia Găman; E Dănăilă; D Coriu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie     Volume:  53     ISSN:  1220-0522     ISO Abbreviation:  Rom J Morphol Embryol     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112454     Medline TA:  Rom J Morphol Embryol     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  197-202     Citation Subset:  IM    
Affiliation:
"Stefan Berceanu" Centre of Hematology and Marrow Transplantation, "Fundeni" Clinical Hospital, Bucharest, Romania; cameliadobrea@yahoo.com.
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