Document Detail


Systemic markers of age-related changes in the lens.
MedLine Citation:
PMID:  22866316     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A dependency was found between total protein content and cataract maturity (P=-0.91, p<0.01). LPO intensity sharply increased and remained stably high after appearance of lens opacity. A strict negative correlation was found between the content of polyunsaturated fatty acids in earwax and lens nucleus (P=-0.7, p<0.01). The content of conjugated dienes, crotonic aldehyde, and Schiff bases decreased during cataract development. The content of vitamins B(2), A, and E decreased with increasing brown coloration of lens nucleus. Studying the parameters of lipid metabolism in wax-producing glands of the external ear canal we can evaluate the disturbances in lipid metabolism in the lens, which was confirmed by the correlation between fatty acid composition of the earwax and lens nucleus. These data do not demonstrate the dependence of the lens state on earwax, but suggest general features of the process in organs and tissues during aging. Some markers in the blood of patients with cataract change during progress of lens opacity and intensification of brown coloration of lens nucleus, but these changes are inspecific and reflect general activation of peroxidation processes and antioxidant system.
Authors:
Yu V Kudryavtseva; A D Chuprov; I P Ivanova; P I Tsapok; V B Tsibel'; E R Bojko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  153     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  375-7     Citation Subset:  IM    
Affiliation:
Kirov Clinical Ophtalmological Hospital; Kirov State Medical Academy; Research Institute of Applied and Basic Medicine, Nizhnii Novgorod State Medical Academy; Komi Branch of Kirov State Medical Academy, Syktyvkar; Institute of Physiology, Komi Research Center, Ural Division of Russian Academy of Sciences, Syktyvkar, Russia. July_Kud@mail.ru.
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