| Systemic mannose-binding lectin is not associated with Chronic Obstructive Pulmonary Disease. | |
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MedLine Citation:
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PMID: 19836222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mannose-binding lectin (MBL) deficiency is associated with increased susceptibility to airways infections and autoimmunity. We examined whether MBL deficiency was more common in COPD patients, and whether MBL deficiency was associated with COPD severity. 415 COPD patients and 231 healthy subjects, aged 40-75, were examined in 2006/07. Plasma MBL levels were determined by ELISA. Low or deficient MBL levels were defined as plasma levels below 500ng/mL or 100ng/mL respectively. Logistic regression models determined factors associated with MBL deficiency; with explanatory variables study category, sex, age, smoking, comorbid heart disease, and CRP. For COPD severity, explanatory variables were FEV1, exacerbation history, hypoxia, respiratory symptoms, inhaled steroids, and CRP. 18.2% of healthy subjects and 22.2% of patients had MBL levels below 100ng/mL (p=0.23); 42.9% of healthy subjects and 49.6% of patients had levels below 500ng/mL (p=0.10). After adjustment for co-variables, patients had an OR (95% CI) of 1.26 (0.7, 2.2) for having MBL levels below 100ng/mL compared with healthy subjects, and an OR (95% CI) of 1.06 (0.7, 1.7) for having levels below 500ng/mL. Among the COPD patients, none of the disease variables were associated with MBL deficiency. No association was found between MBL deficiency and COPD or COPD severity. |
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Authors:
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Tomas Ml Eagan; Pål Aukrust; Per S Bakke; Jan Kristian Damås; Trude D Skorge; Jon A Hardie; Thor Ueland; Tom Eirik Mollnes |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiratory medicine Volume: 104 ISSN: 1532-3064 ISO Abbreviation: Respir Med Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 283-90 Citation Subset: IM |
Affiliation:
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Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway. tomas.eagan@med.uib.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Disease Susceptibility / blood Female Humans Immunocompetence / genetics, physiology Male Mannose-Binding Lectin / blood*, deficiency, genetics Middle Aged Norway Predictive Value of Tests Pulmonary Disease, Chronic Obstructive / blood*, genetics, physiopathology Retrospective Studies Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Mannose-Binding Lectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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