| [Systemic manifestations and comorbidities in patients with chronic obstructive pulmonary disease (COPD) and their effect on clinical state and course of the disease--an overview of the cohort study COSYCONET]. | |
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MedLine Citation:
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PMID: 20198540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The integrated project COSYCONET, as part of the competence network ASCONET funded by the BMBF, has the aim to investigate the relationship between the pulmonary disorder, comorbidities and systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) by adopting cross-sectional as well as longitudinal analyses. METHODOLOGICAL APPROACH: COSYCONET includes a number of projects addressing the issue of comorbidities at the basic science level. Its core project, however, is the establishment of a cohort of patients with COPD, which is compared with two population-based control cohorts. The COPD cohort will include 3,000 patients, among them 1,500 with severity according to GOLD category I/II and 1,500 with category III/IV. Patients will be recruited in study centers covering all major regions of Germany, and this will be achieved in close cooperation with pneumologists from private practices. After recruitment, patients will be studied upon an initial visit as well as 6 and 18 months later. Each visit includes a comprehensive battery of functional tests and questionnaires that aim at assessing the state of the disease as accurately and completely as feasible, comprising lung function and the individual pattern and risk factors of comorbidities including cardiovascular disorders, metabolic disorders, osteoporosis, exercise capacity, acticity and mental status. In addition blood samples will be taken and asservated in a biobank in order to assess markers of systemic inflammation and aging as well as organ-specific markers. Moreover morphological information on the lung as available from HR-CT pictures that have not been specifically taken for the study will be analysed semi-quantitatively in a central facility and standardised manner. |
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Authors:
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R A Jörres; T Welte; R Bals; A Koch; M Schnoor; C Vogelmeier |
Publication Detail:
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Type: English Abstract; Journal Article Date: 2010-03-02 |
Journal Detail:
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Title: Deutsche medizinische Wochenschrift (1946) Volume: 135 ISSN: 1439-4413 ISO Abbreviation: Dtsch. Med. Wochenschr. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-03 Completed Date: 2010-04-02 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0006723 Medline TA: Dtsch Med Wochenschr Country: Germany |
Other Details:
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Languages: ger Pagination: 446-9 Citation Subset: IM |
Copyright Information:
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Georg Thieme Verlag KG Stuttgart , New York. |
Affiliation:
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Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin der LMU München. rudolf.joerres@med.uni-muenchen.de |
Vernacular Title:
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Einfluss systemischer Manifestationen und Komorbiditäten auf den klinischen Zustand und den Verlauf bei COPD. Eine Ubersicht über die Kohortenstudie COSYCONET. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Cause of Death Cohort Studies Comorbidity Cross-Sectional Studies Female Germany Humans Image Enhancement Inflammation Mediators / blood Life Style Longitudinal Studies Male Multicenter Studies as Topic Pulmonary Disease, Chronic Obstructive / diagnosis*, epidemiology*, mortality Quality Assurance, Health Care Research Design Respiratory Function Tests Risk Factors Sex Factors Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Inflammation Mediators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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