| Systemic lupus erythematosus, regulatory T cells and pregnancy. | |
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MedLine Citation:
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PMID: 21895476 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Systemic lupus erythematosus (SLE) is the most common autoimmune disease affecting women of reproductive age and is associated with poor maternal and fetal outcomes. CD4(+)CD25(+) Treg cells are a subset of T lymphocytes with potent immunosuppressive activity that play crucial roles in controlling immunological self tolerance. Evidence suggests that they are augmented in pregnancy, especially in the first trimester, suggesting an important role in early placental development. The literature describing Treg cells in SLE is conflicting, but SLE is associated with reduced numbers and functionally defective Treg cells, which may predispose pregnant women with the disease to pregnancy complications. This article discusses the role of Treg cells in SLE and pregnancy, and how these cells may contribute to poor pregnancy outcome in SLE-affected women. |
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Authors:
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Stephy Varghese; Ian Crocker; Ian N Bruce; Clare Tower |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of clinical immunology Volume: 7 ISSN: 1744-8409 ISO Abbreviation: Expert Rev Clin Immunol Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101271248 Medline TA: Expert Rev Clin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 635-48 Citation Subset: IM |
Affiliation:
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Maternal and Fetal Health Research Centre, University of Manchester, St Mary's hospital, Manchester M13 9WL, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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