Document Detail

Systemic lupus erythematosus and multiple myeloma: an uncommon association. Two cases and literature review.
MedLine Citation:
PMID:  18799103     Owner:  NLM     Status:  MEDLINE    
The association of systemic lupus erythematosus and multiple myeloma is uncommon. We report two cases of systemic lupus erythematosus associated to multiple myeloma. The cases are discussed in the light of a review of the literature. The clinical, laboratory and radiographic findings of the patients, as well as the subsequent therapeutic approach are discussed. A systematic review of all the other cases of this association is performed. We report two female patients of 50 and 35 years old who developed a multiple myeloma seven and three years respectively after the diagnosis of systemic lupus erythematosus. In the second case, systemic lupus erythematosus was associated to monoclonal gammopathy. One patient died after three months and one patient is still in remission after three years of the diagnosis of multiple myeloma. The coexistence of systemic lupus erythematosus and multiple myeloma is very rare and the possible pathogenetic mechanisms underlying this association remain unclear.
M Maamar; Z Tazi Mezalek; H Harmouche; M Adnaoui; M Aouni; A Maaouni
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  26     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-09-18     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  667-70     Citation Subset:  IM    
Department of Internal Medicine, Ibn Sina Hospital, Rabat, Morocco.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols
Fatal Outcome
Lupus Erythematosus, Systemic / complications*
Melphalan / therapeutic use
Middle Aged
Multiple Myeloma / complications*,  drug therapy
Prednisone / therapeutic use
Remission Induction
Reg. No./Substance:
0/VAD regimen; 147-94-4/Cytarabine; 148-82-3/Melphalan; 50-02-2/Dexamethasone; 53-03-2/Prednisone; 57-22-7/Vincristine

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