Document Detail

Systemic lupus erythematosus complicated by recurrent pneumothorax: Case report and literature review.
MedLine Citation:
PMID:  20601838     Owner:  NLM     Status:  MEDLINE    
Pneumothorax is a rare pleuropulmonary manifestation of systemic lupus erythematosus. We encountered a 37-year-old Japanese woman who had systemic lupus erythematosus complicated by recurrent pneumothorax during treatment for recurrent serositis with glucocorticoid therapy. She was admitted for the third episode of lupus peritonitis in December 2005. Intravenous cyclophoshamide and increased dose of oral prednisolone were administered. In early January 2006, hemoptysis was observed and bronchofiberscopy revealed hemorrhage from the left lower lobe. After intravenous methylprednisolone pulse therapy and oral cyclosporine therapy were added, pleurisy and pulmonary hemorrhage improved. On February 22nd, she suddenly developed pneumothorax on the right side, followed by pneumothorax on the left side after 2 days. This pneumothorax on the left side did not improve despite chest tube drainage for over one month. She underwent thoracoscopic partial lobectomy of lower lobe of the left lung, and her symptoms improved. Review of the literature identified 10 case reports of systemic lupus erythematosus complicated by pneumothorax. All of the patients including our case had underlying pulmonary lesions, and 9/11 patients had pleurisy. Besides 10/11 patients received glucocorticoid therapy before the occurrence of pneumothorax. Tissue fragility caused by these factors might contribute to the complication of pneumothorax in patients with systemic lupus erythematosus.
Nahoko Tanaka; Yoshie Kusunoki; Kaichi Kaneko; Tatsuhiro Yamamoto; Makoto Kaburaki; Sei Muraoka; Haruo Abe; Hirahito Endo; Daisuke Sato; Sakae Homma; Kazutoshi Shibuya; Shinichi Kawai
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology     Volume:  33     ISSN:  1349-7413     ISO Abbreviation:  Nihon Rinsho Meneki Gakkai Kaishi     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505992     Medline TA:  Nihon Rinsho Meneki Gakkai Kaishi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  162-8     Citation Subset:  IM    
Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine.
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MeSH Terms
Lupus Erythematosus, Systemic / complications*
Pneumothorax / complications*

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