Document Detail

Systemic lupus erythematosus-associated lymphoproliferative disorder: report of a case and discussion in light of the literature.
MedLine Citation:
PMID:  9269836     Owner:  NLM     Status:  MEDLINE    
A case of autoimmune disease-associated lymphadenopathy (ADAL) with histological, immunophenotypic, Epstein-Barr virus (EBV) in situ hybridization, and genotypic analyses is presented. The patient had a well-documented history of systemic lupus erythematosus (SLE) and was found at autopsy to have massive lymphadenopathy, thymic enlargement, pulmonary nodules, and polyclonal serum dysproteinemia. Histological examination revealed a polymorphous lymphoid infiltrate containing many plasma cells, rare immunoblasts, and a pronounced arborizing vasculature. No foci of necrosis were found and there was no evidence of lymphocyte depletion. The plasma cells were immunophenotypically polyclonal and no EBV mRNA (EBER-1) or gene rearrangements were identified. The unusual gross features, which resembled a malignant lymphoproliferative process, as well as the unusual histological features make this case a notable addition to the spectrum of atypical lymphoproliferative disorders associated with an autoimmune disorder. We conclude that although reminiscent of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD), this case lacks the diagnostic features of AILD, and is, perhaps, best classified as an autoimmune disease-associated lymphadenopathy (ADAL).
R Blanco; B McLaren; B Davis; P Steele; R Smith
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human pathology     Volume:  28     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-18     Completed Date:  1997-09-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  980-5     Citation Subset:  IM; X    
Department of Pathology and Laboratory Medicine, University of Cincinnati Medical College, OH 45267-0529, USA.
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MeSH Terms
Fatal Outcome
In Situ Hybridization
Lung / pathology
Lupus Erythematosus, Systemic / diagnosis*
Lymph Nodes / pathology
Lymphoproliferative Disorders / diagnosis*
RNA, Viral / analysis,  genetics
Thymus Gland / pathology
Reg. No./Substance:
0/Epstein-Barr virus encoded RNA 1; 0/RNA, Viral

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