| Systemic lupus erythematosus after thymectomy for myasthenia gravis: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 20054604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here, we report a case of systemic lupus erythematosus in a 13-year-old girl who developed the disease 3 years after thymectomy performed for the treatment of myasthenia gravis. The presenting symptoms were fever, generalized fatigability, bilateral loin pain, weight loss, arthralgia, hair loss, and recurrent painless mouth ulcers. Laboratory findings revealed proteinuria, hematuria, anemia, leucopenia, a high titer of antinuclear antibodies (ANA), anti-dsDNA, and decreased complement (C3 and C4) levels. There was minimal ascitis and pericardial effusion. Renal biopsy showed lupus nephritis class IV. The diagnosis of systemic lupus erythematosus was established based on the clinical and laboratory findings. The activity of systemic lupus erythematosus was controlled by pulsed treatment with methyl prednisolone followed by long-term oral glucocorticoid and immunosuppressive therapy. This study highlights the immune system derangement following thymectomy. It also examines the relevant literature. |
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Authors:
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Hyder A Omar; Mohammed A Alzahrani; Ali A A Al Bshabshe; Alhussain Assiri; Medhat Shalaby; Ahmad Dwedar; Saad Rezk Abdulwahed; Mahmoud Rezk-Abd-Elwahed Hussein |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2010-01-07 |
Journal Detail:
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Title: Clinical and experimental nephrology Volume: 14 ISSN: 1437-7799 ISO Abbreviation: Clin. Exp. Nephrol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709923 Medline TA: Clin Exp Nephrol Country: Japan |
Other Details:
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Languages: eng Pagination: 272-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, College of Medicine, King Khalid University, Asser Central Hospital, Abha, Kingdom of Saudi Arabia. [corrected] |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Female Humans Immunosuppressive Agents / therapeutic use Lupus Erythematosus, Systemic / drug therapy, etiology* Methylprednisolone / therapeutic use Myasthenia Gravis / surgery* Thymectomy / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 83-43-2/Methylprednisolone |
| Comments/Corrections | |
Erratum In:
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Clin Exp Nephrol. 2010 Jun;14(3):277 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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