Document Detail

Systemic and local reactions of bee venom immunotherapy in Iran.
MedLine Citation:
PMID:  18094443     Owner:  NLM     Status:  MEDLINE    
Severe allergic reactions during specific immunotherapy may occur in the treatment of hymenoptera sting allergy. The objective of the present study was to examine the characteristics of allergic reactions during specific immunotherapy in patients with allergy towards hymenoptera venom in the Iranian population. A prospective study was performed using the clinical reports of 27 patients with anaphylaxis to bee venom (Apis melifera, Geupes vespula and Geupes Polites). Ten patients treated with Cluster protocol during 2002 and 2006 After diagnosis of hymenoptera sting allergy according to history and intradermal tests, the patient were treated with Cluster protocol immunotherapy. The protocol lasted 6 weeks with an increase in the concentration of venom from 0.01 microg/ml to 100 microg/ml. None of the patient received premedication. All patients with hymenoptera venom allergy received 120 injections. Anaphylactic reactions were classified according to the Mueller-classification. The frequencies of systemic reactions during Cluster protocol were 8.33% and 5% for yellow jacket and honey bee venom respectively. No patient experienced severe systemic reaction. Cluster protocol for hymenoptera immunotherapy is a reliable method for the treatment of anaphylactic reactions to bee venom. It is safe with low cost and do not need hospitalization.
Mohammad Hassan Bemanian; Abolhassan Farhoudi; Zahra Pourpak; Mohammad Gharagozlou; Masoud Movahedi; Mohammad Nabavi; Habibeh Mozafari; Iraj Mohammadzadeh; Zahra Chavoshzadeh; Zahra Shirkhoda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of allergy, asthma, and immunology     Volume:  6     ISSN:  1735-1502     ISO Abbreviation:  Iran J Allergy Asthma Immunol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-20     Completed Date:  2008-07-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101146178     Medline TA:  Iran J Allergy Asthma Immunol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  203-6     Citation Subset:  IM    
Department of Pediatrics, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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MeSH Terms
Anaphylaxis / etiology,  immunology,  therapy
Bee Venoms / immunology*
Desensitization, Immunologic*
Hymenoptera / immunology*
Hypersensitivity / etiology*,  immunology
Immunoglobulin E / blood,  immunology
Immunotherapy / adverse effects
Insect Bites and Stings / immunology*
Skin Tests
Reg. No./Substance:
0/Bee Venoms; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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