Document Detail

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis.
MedLine Citation:
PMID:  19196728     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Th17 cells are an effector T-cell population that plays a role in chronic inflammatory conditions and is dependent on IL-23 for their survival and expansion. More recently, a genetic association was discovered between polymorphisms in the gene coding for the IL-23 receptor and spondyloarthritis. This study aimed to evaluate the role of Th17-associated cytokines in spondyloarthritis pathogenesis by measuring their levels in the joints and circulation as well as correlating them with disease activity parameters. METHODS: Paired synovial fluid (SF), serum and synovial biopsies were obtained from 30 non-PsA (psoriatic arthritis) spondyloarthritis, 22 PsA and 22 rheumatoid arthritis (RA) patients. IL-17, IL-23 and CCL20 were measured by ELISA in the SF and serum of patients and correlated with systemic and local parameters of disease activity. RESULTS: Concentrations of CCL20, a major Th17-attracting chemokine, tended to be higher in the joints of RA than in spondyloarthritis patients. Interestingly, levels of CCL20 were markedly higher in SF as opposed to serum. In addition, there was a remarkable association between the expression of the Th17 cytokine system and the presence of intimal lining layer hyperplasia in RA. Also in the serum, there was a tendency for higher IL-23 levels in RA, which correlated strongly with disease activity parameters. CONCLUSIONS: Th17-related cytokines are expressed in joints of spondyloarthritis as well as RA patients. IL-23 levels, however, correlate with disease activity parameters in RA only. These results point towards a differential regulation of the Th17 cytokine system in spondyloarthritis compared with RA.
Lode Melis; Bernard Vandooren; Elli Kruithof; Peggy Jacques; Martine De Vos; Herman Mielants; Gust Verbruggen; Filip De Keyser; Dirk Elewaut
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-05
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  69     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-12     Completed Date:  2010-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  618-23     Citation Subset:  IM    
Department of Rheumatology, Ghent University Hospital, Belgium.
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MeSH Terms
Arthritis, Psoriatic / immunology,  metabolism
Arthritis, Rheumatoid / immunology,  metabolism*
Chemokine CCL20 / immunology,  metabolism*
Cohort Studies
Interleukin-17 / metabolism*
Interleukin-23 / metabolism*
Middle Aged
Spondylarthritis / immunology,  metabolism*
Synovial Fluid / immunology,  metabolism*
Reg. No./Substance:
0/CCL20 protein, human; 0/Chemokine CCL20; 0/Interleukin-17; 0/Interleukin-23

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