Document Detail

Systemic leishmaniasis mimicking malignant histiocytosis.
MedLine Citation:
PMID:  216478     Owner:  NLM     Status:  MEDLINE    
A 22-year-old man with fever, hepato-splenomegaly and severe pancytopenia is described in whom the histologic features of the spleen, liver and lymph nodes were consistent with malignant histiocytosis. Characteristic Leishman-Donovan bodies were demonstrated on a bone marrow aspirate, and the diagnosis of visceral leishmaniasis was confirmed by culturing the flagellated forms of the pathogen, and by an excellent response to sodium stibogluconate. In view of the similarity in clinical and histologic appearance, visceral leishmaniasis must be considered in the differential diagnosis of malignant histiocytosis in geographic areas where leishmaniasis is still endemic.
Y Matzner; A Behar; E Beeri; A E Gunders; C Hershko
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  43     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-04-26     Completed Date:  1979-04-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  398-402     Citation Subset:  AIM; IM    
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MeSH Terms
Antimony Sodium Gluconate / therapeutic use
Bone Marrow / microbiology
Diagnosis, Differential
Histiocytes / microbiology
Leishmaniasis, Visceral / diagnosis*,  drug therapy
Liver / pathology
Lymph Nodes / pathology
Lymphatic Diseases / diagnosis*
Spleen / pathology
Reg. No./Substance:
0/Antimony Sodium Gluconate

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