Document Detail


Systemic lactose intolerance: a new perspective on an old problem.
MedLine Citation:
PMID:  15749792     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intolerance to certain foods can cause a range of gut and systemic symptoms. The possibility that these can be caused by lactose has been missed because of "hidden" lactose added to many foods and drinks inadequately labelled, confusing diagnosis based on dietary removal of dairy foods. Two polymorphisms, C/T13910 and G/A22018, linked to hypolactasia, correlate with breath hydrogen and symptoms after lactose. This, with a 48 hour record of gut and systemic symptoms and a six hour breath hydrogen test, provides a new approach to the clinical management of lactose intolerance. The key is the prolonged effect of dietary removal of lactose. Patients diagnosed as lactose intolerant must be advised of "risk" foods, inadequately labelled, including processed meats, bread, cake mixes, soft drinks, and lagers. This review highlights the wide range of systemic symptoms caused by lactose intolerance. This has important implications for the management of irritable bowel syndrome, and for doctors of many specialties.
Authors:
S B Matthews; J P Waud; A G Roberts; A K Campbell
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  81     ISSN:  1469-0756     ISO Abbreviation:  Postgrad Med J     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-07     Completed Date:  2005-06-16     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  England    
Other Details:
Languages:  eng     Pagination:  167-73     Citation Subset:  IM    
Affiliation:
Department of Medical Biochemistry and Immunology, Llandough Hospital, Cardiff and Vale NHS Trust, Penarth Vale of Glamorgan, UK.
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MeSH Terms
Descriptor/Qualifier:
Asthma / etiology
Breath Tests / methods
Eczema / etiology
Female
Humans
Irritable Bowel Syndrome / etiology
Lactase / deficiency
Lactose Intolerance / complications,  diagnosis*,  diet therapy
Lactose Tolerance Test / methods
Middle Aged
Osteoarthritis / etiology
Chemical
Reg. No./Substance:
EC 3.2.1.108/Lactase
Comments/Corrections

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