Document Detail

Systemic itraconazole in the yellow nail syndrome.
MedLine Citation:
PMID:  12072079     Owner:  NLM     Status:  MEDLINE    
Although a number of treatments have been reported to be effective with yellow nail syndrome (YNS), vitamin E at high doses is the only one that has been successfully utilized in a consistent number of patients affected by YNS. Recent data indicate that itraconazole pulse regimen may be effective in this disease. We report our experience with itraconazole treatment in patients affected by YNS. Systemic itraconazole was administered in eight patients (five males and three females; mean age 55.2 years), at a dosage of 400 mg daily for 1 week a month for 6 months. Nail growth was measured every 3 months. Complete cure was achieved in two of eight patients, with mild improvement in two and no improvement in four. The results of our study show that itraconazole cannot be considered effective for YNS, especially if compared with vitamin E, the efficacy and tolerability of which is already proven.
A Tosti; B M Piraccini; M Iorizzo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  146     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-19     Completed Date:  2002-09-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1064-7     Citation Subset:  IM    
Department of Dermatology, University of Bologna, Via Massarenti 1, 40138 Bologna, Italy.
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MeSH Terms
Antifungal Agents / therapeutic use*
Itraconazole / therapeutic use*
Middle Aged
Nail Diseases / drug therapy*
Pigmentation Disorders / chemically induced*
Reg. No./Substance:
0/Antifungal Agents; 84625-61-6/Itraconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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