| Systemic inflammatory response syndrome in nonhuman primates culminating in multiple organ failure, acute lung injury, and disseminated intravascular coagulation. | |
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MedLine Citation:
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PMID: 19773593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The systemic inflammatory response syndrome (SIRS) is a clinicopathological manifestation of overexuberant acute-phase inflammation caused by infectious or noninfectious etiologies. The systemic release of pro-inflammatory cytokines, chemokines, and lipid and vasoactive mediators induces endothelial damage and microvascular thrombosis, potentially culminating in disseminated intravascular coagulation (DIC), acute respiratory distress syndrome (ARDS), and multiple organ dysfunction (MOD) or failure (MOF). We present five cases in the pig-tailed macaque and olive baboon where SIRS resulted in MOF, ARDS, DIC, and the Waterhouse-Friderichsen syndrome; each with gross and histological elements manifested as edema, deposition of fibrin, hemorrhage, and thrombosis. In the described cases, SIRS was the end-common pathway for multiple risk factors that parallel those documented in humans: major surgery, obstetric complications, and infection. The diagnosis of SIRS should be considered when evaluating nonhuman primate (NHP) cases of MOF manifesting with histological evidence of vascular leakage. Experimental manipulation of NHP models may be complicated by SIRS and accompanying rapid clinical decompensation. Such adverse events may compromise toxicological studies and should be avoided when possible. |
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Authors:
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Renee R Hukkanen; H Denny Liggitt; Robert D Murnane; Charles W Frevert |
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12495303 - Intravascular lymphomatosis presenting as systemic inflammatory response syndrome. 9499193 - Hemolytic uremic syndrome in prostatic carcinoma. 2254613 - Horner's syndrome in the emergency department. |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Toxicologic pathology Volume: 37 ISSN: 1533-1601 ISO Abbreviation: Toxicol Pathol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-23 Completed Date: 2010-01-15 Revised Date: 2012-01-05 |
Medline Journal Info:
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Nlm Unique ID: 7905907 Medline TA: Toxicol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 799-804 Citation Subset: IM |
Affiliation:
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University of Washington, Department of Comparative Medicine, Seattle, Washington 98195-7190, USA. rgamboa@wanprc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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blood,
pathology,
veterinary* Animals Cytokines / metabolism Disseminated Intravascular Coagulation / blood, pathology, veterinary* Female Macaca nemestrina Male Multiple Organ Failure / blood, pathology, veterinary* Papio anubis Risk Factors Systemic Inflammatory Response Syndrome / blood, pathology, veterinary* |
| Grant Support | |
ID/Acronym/Agency:
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P51 RR000166/RR/NCRR NIH HHS; R21 RR030249-02/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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