Document Detail

Systemic inflammatory response and the splanchnic bed in cardiopulmonary bypass.
MedLine Citation:
PMID:  8817628     Owner:  NLM     Status:  MEDLINE    
The splanchnic bed undoubtedly undergoes sub-clinical injury in the majority of patients undergoing routine CPB. Dependent upon patient and perfusion factors, this injury may be self-limiting or develop through a cascade of inflammatory mediators into multisystem organ failure. The gut may be damaged by the bioincompatibility of CPB, but it is, as a consequence of hypoperfusion and dysoxia, also a major source of bacterial and nonbacterial inflammatory mediators.
S K Ohri
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Perfusion     Volume:  11     ISSN:  0267-6591     ISO Abbreviation:  Perfusion     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-29     Completed Date:  1996-11-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8700166     Medline TA:  Perfusion     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  200-12     Citation Subset:  IM    
Cardiothoracic Unit, Hammersmith Hospital, Royal Postgraduate Medical School, London, UK.
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MeSH Terms
Anoxia / etiology
Cardiopulmonary Bypass / adverse effects*
Inflammation / etiology*
Inflammation Mediators / physiology
Intestinal Absorption
Intestinal Mucosa / metabolism
Postoperative Complications / etiology*
Splanchnic Circulation*
Reg. No./Substance:
0/Inflammation Mediators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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