| Systemic inflammation and the metabolic syndrome among middle-aged community volunteers. | |
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MedLine Citation:
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PMID: 20619428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolic syndrome is conceptualized as a clustering of risk factors--including insulin resistance, dyslipidemia, central adiposity, and elevated blood pressure (BP)--that increase the risk for cardiovascular disease and type 2 diabetes mellitus. Recent evidence suggests that markers of systemic inflammation may be included in the definition of the syndrome and play some role in its pathogenesis. In this study, we use a statistical modeling technique, confirmatory factor analysis, to evaluate relationships of systemic inflammation, as measured by plasma concentrations of C-reactive protein and interleukin-6, with the component factors of the metabolic syndrome (insulin resistance, dyslipidemia, central adiposity, and elevated BP) and to examine whether inflammation is a potential common pathway linking established components to the full syndrome. Subjects were 645 community volunteers aged 30 to 54 years (48% male, 82% European American, 18% African American). Consistent with existing literature, structural equation modeling adjusting for age, sex, and race confirmed a higher-order common factor underlying the covariation of insulin resistance, dyslipidemia, adiposity, and BP. Inflammation was positively associated with this common factor, accounting for 54% of its variance and partially mediating statistical aggregation of the component factors comprising the metabolic syndrome. These results were particularly strong for adiposity, raising the possibility that inflammatory processes stimulated by intraabdominal adipose tissue contribute to the development of the metabolic syndrome. The inclusion of inflammatory markers in the clinical definition of metabolic syndrome seems warranted and may improve prognostic assessment of risk of type 2 diabetes mellitus and cardiovascular disease. |
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Authors:
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Anna L Marsland; Jeanne M McCaffery; Matthew F Muldoon; Stephen B Manuck |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 59 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-23 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 1801-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA. marsland@pitt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Inflammation / complications* Male Metabolic Syndrome X / complications* Middle Aged Models, Theoretical Voluntary Workers* |
| Grant Support | |
ID/Acronym/Agency:
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NR008237/NR/NINR NIH HHS; P01 HL040962-19/HL/NHLBI NIH HHS; P01HL40962/HL/NHLBI NIH HHS; R01 NR008237-05/NR/NINR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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