Document Detail

Systemic inflammation and left atrial thrombus in patients with non-rheumatic atrial fibrillation.
MedLine Citation:
PMID:  20466519     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is an apparent link between thrombogenesis and inflammation. We hypothesized that systemic inflammation [as indicated by C-reactive protein (CRP)] would be related to the presence of left atrial (LA) thrombus in patients with atrial fibrillation (AF). To test this hypothesis, we evaluated the relationship between CRP and LA thrombus in patients with non-rheumatic AF. METHODS AND RESULTS: Between October 2004 and December 2008, 190 patients with non-rheumatic AF (122 males, age 71+/-10 years) who underwent transesophageal echocardiography (TEE) were enrolled and analyzed. All patients were examined for presence or absence of LA thrombus by TEE. CRP was measured within 1 week before the TEE examination. LA thrombus was detected in 19 patients (10%). Hypertension, hypertensive heart disease (HHD), valvular heart disease, ticlopidine, and CRP were univariate correlates of LA thrombus. By multivariate analysis, HHD (p<0.01), ticlopidine (p=0.01), and CRP (p=0.03) were independently associated with LA thrombus. A cut-off CRP value for identifying LA thrombus was 0.21mg/dl (sensitivity: 84%, specificity: 60%, positive predictive value: 19%, and negative predictive value: 97%). CONCLUSION: A high CRP is related to LA thrombus in patients with non-rheumatic AF.
Tomoko Maehama; Hiroyuki Okura; Koichiro Imai; Ken Saito; Ryotaro Yamada; Terumasa Koyama; Akihiro Hayashida; Yoji Neishi; Takahiro Kawamoto; Kiyoshi Yoshida
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Publication Detail:
Type:  Journal Article     Date:  2010-05-13
Journal Detail:
Title:  Journal of cardiology     Volume:  56     ISSN:  0914-5087     ISO Abbreviation:  J Cardiol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  118-24     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Department of Cardiology, Kawasaki Medical School, Matsushima 577, Kurashiki, Okayama 701-0192, Japan.
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MeSH Terms
Aged, 80 and over
Atrial Fibrillation / blood,  pathology*,  ultrasonography
C-Reactive Protein / analysis
Echocardiography, Transesophageal
Heart Atria / pathology*
Inflammation / blood,  complications*
Middle Aged
Thrombosis / pathology*
Reg. No./Substance:
9007-41-4/C-Reactive Protein

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