| Systemic inflammation in the elderly. | |
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MedLine Citation:
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PMID: 21925406 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Inflammation is an adaptive response to surgery. When the pro-inflammatory responses are unregulated and become over reactive, systemic inflammatory response syndrome may occur. Postoperative systemic inflammation is more common than is generally acknowledged and is observed in about 10-15% of elderly patients undergoing major surgery. Although the vast majority of systemic inflammation is related to infections, other important predisposing risk factors, such as extent of trauma and haemorrhage, should not be overlooked. Increased awareness, modification of risk factors and early recognition are the key elements in the management of systemic inflammation. Prompt resuscitation aiming to correct hypotension, hypovolaemia and tissue hypoxia may improve outcome. Future large prospective observational studies are needed to define the incidence, risk factors and impact of systemic inflammatory syndrome in the elderly surgical patients. A better understanding of the molecular events during the systemic inflammatory response syndrome is required for future development of specific immunotherapy. |
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Authors:
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Emily G Y Koo; Linda M L Lai; Gordon Y S Choi; Matthew T V Chan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Best practice & research. Clinical anaesthesiology Volume: 25 ISSN: 1521-6896 ISO Abbreviation: Best Pract Res Clin Anaesthesiol Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101121446 Medline TA: Best Pract Res Clin Anaesthesiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 413-25 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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