Document Detail

Systemic inflammation in chronic obstructive pulmonary disease and asthma: Similarities and differences.
MedLine Citation:
PMID:  18197923     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: While recent studies have shown that patients with COPD and patients with asthma exhibit evidence of airway and systemic inflammation, markers of systemic inflammation have not been compared between the two diseases. METHODS: To evaluate circulating inflammatory markers, blood was sampled from 111 patients with COPD, 75 control subjects and 46 asthmatic patients (some of whom were smokers). Measurements of WCC, serum levels of fibrinogen, high-sensitivity (hs)-CRP, IL-8, IL-6, tumour necrosis factor-alpha (TNF-alpha), transforming growth factor (TGF)-beta1, tissue inhibitors of metalloproteinase (TIMP)-1, neutrophil elastase and alpha1-antitrypsin (alpha1-AT) were performed. RESULTS: Serum TNF-alpha, IL-6 and TIMP-1 concentrations were significantly higher in patients with stable COPD and patients with asthma than in control patients. Serum alpha1-AT levels were significantly higher in COPD patients than in asthmatic patients and control subjects, and serum TGF-beta1 levels were higher in asthma patients than in COPD patients. Smoking status had no effect on markers in COPD and asthmatic patients. CONCLUSIONS: Although COPD and asthma share common markers of systemic inflammation, serum levels of TGF-beta1 and alpha1-AT may reflect differences between the diseases.
Yuji Higashimoto; Yuko Yamagata; Satoshi Taya; Takuya Iwata; Morihiro Okada; Tadashi Ishiguchi; Hiroaki Sato; Hidekazu Itoh
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  13     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-16     Completed Date:  2008-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  128-33     Citation Subset:  IM    
Department of Internal Medicine, Wakayama Medical University Kihoku Hospital, Wakayama Prefecture, Japan.
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MeSH Terms
Acute-Phase Proteins / metabolism*
Asthma / metabolism*,  pathology*
Case-Control Studies
Cytokines / blood
Inflammation Mediators / blood*
Leukocyte Elastase / blood
Middle Aged
Pulmonary Disease, Chronic Obstructive / metabolism*,  pathology*
Respiratory Function Tests
Smoking / adverse effects
Tissue Inhibitor of Metalloproteinase-1 / blood
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Cytokines; 0/Inflammation Mediators; 0/Tissue Inhibitor of Metalloproteinase-1; EC Elastase

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