Document Detail

Systemic inflammation and carotid diameter in obese patients: pilot comparative study with flaxseed powder and cassava powder.
MedLine Citation:
PMID:  21519749     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Botanical omega-3 fatty acid (alphalinolenic acid/ALA) has been shown to alleviate the prothrombotic and proinflammatory profile of metabolic syndrome, however clinical protocols are still scarce. Aiming to focus an obese population, a pilot study was designed.
METHODS: Morbidly obese candidates for bariatric surgery (n = 29, age 46.3 ± 5.2 years), 82.8% females (24/29), BMI 44.9 ± 5.2 kg/m², with C-reactive protein/CRP > 5 mg/L were recruited. Twenty were randomized and after exclusions, 16 were available for analysis. Flaxseed powder (60 g/day, 10 g ALA) and isocaloric roasted cassava powder (60 g/day, fat-free) were administered in a double-blind routine for 12 weeks.
RESULTS: During flaxseed consumption neutrophil count decreased and fibrinogen, complement C4, prothrombin time and carotid diameter remained stable, whereas placebo (cassava powder) was associated with further elevation of those measurements.
CONCLUSIONS: Inflammatory and coagulatory markers tended to exhibit a better outlook in the flaxseed group. Also large-artery diameter stabilized whereas further increase was noticed in controls. These findings raise the hypothesis of a less deleterious cardiovascular course in seriously obese subjects receiving a flaxseed supplement.
J Faintuch; L A Bortolotto; P C Marques; J J Faintuch; J I França; I Cecconello
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrición hospitalaria     Volume:  26     ISSN:  1699-5198     ISO Abbreviation:  Nutr Hosp     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-04-26     Completed Date:  2011-09-01     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9100365     Medline TA:  Nutr Hosp     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  208-13     Citation Subset:  IM    
Nutrology Residency Program, Hospital das Clinicas, São Paulo, Brazil.
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MeSH Terms
Body Weight / physiology
Carotid Artery, Common / pathology*,  ultrasonography
Dietary Supplements
Double-Blind Method
Femoral Artery / physiology
Flax / chemistry*
Inflammation / diet therapy*,  etiology,  pathology
Manihot / chemistry*
Middle Aged
Nutritional Status
Obesity, Morbid / diet therapy*,  pathology
Pilot Projects
Prospective Studies
Sample Size
Reg. No./Substance:

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