Document Detail


Systemic inflammation associated with mechanical ventilation among extremely preterm infants.
MedLine Citation:
PMID:  23148992     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little evidence is available to document that mechanical ventilation is an antecedent of systemic inflammation in preterm humans. We obtained blood on postnatal day 14 from 726 infants born before the 28th week of gestation and measured the concentrations of 25 inflammation-related proteins. We created multivariable models to assess the relationship between duration of ventilation and protein concentrations in the top quartile. Compared to newborns ventilated for fewer than 7 days (N=247), those ventilated for 14 days (N=330) were more likely to have elevated blood concentrations of pro-inflammatory cytokines (IL-1β, TNF-α), chemokines (IL-8, MCP-1), an adhesion molecule (ICAM-1), and a matrix metalloprotease (MMP-9), and less likely to have elevated blood concentrations of two chemokines (RANTES, MIP-1β), a matrix metalloproteinase (MMP-1), and a growth factor (VEGF). Newborns ventilated for 7-13 days (N=149) had systemic inflammation that approximated the pattern of newborns ventilated for 14 days. These relationships were not confounded by chorioamnionitis or antenatal corticosteroid exposure, and were not altered appreciably among infants with and without bacteremia. These findings suggest that 2 weeks of ventilation are more likely than shorter durations of ventilation to be accompanied by high blood concentrations of pro-inflammatory proteins indicative of systemic inflammation, and by low concentrations of proteins that might protect from inflammation-mediated organ injury.
Authors:
Carl L Bose; Matthew M Laughon; Elizabeth N Allred; T Michael O'Shea; Linda J Van Marter; Richard A Ehrenkranz; Raina N Fichorova; Alan Leviton;
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-11
Journal Detail:
Title:  Cytokine     Volume:  61     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-23     Completed Date:  2013-06-19     Revised Date:  2014-03-27    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  315-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Chemokine CCL2 / blood
Chemokine CCL4 / blood
Chemokine CCL5 / blood
Chemokines / blood
Chorioamnionitis / blood
Cytokines / blood*
Female
Humans
Infant, Extremely Premature*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases*
Inflammation / blood
Intercellular Adhesion Molecule-1 / blood
Interleukin-1beta / blood
Interleukin-8 / blood
Male
Matrix Metalloproteinase 9 / blood
Pregnancy
Respiration, Artificial / adverse effects*
Systemic Inflammatory Response Syndrome*
Tumor Necrosis Factor-alpha / blood
Vascular Endothelial Growth Factor A / blood
Grant Support
ID/Acronym/Agency:
5P30HD018655-28/HD/NICHD NIH HHS; 5U01NS040069-05/NS/NINDS NIH HHS; K23 HD068497/HD/NICHD NIH HHS; U01 NS040069/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/CCL2 protein, human; 0/CCL5 protein, human; 0/Chemokine CCL2; 0/Chemokine CCL4; 0/Chemokine CCL5; 0/Chemokines; 0/Cytokines; 0/Interleukin-1beta; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 126547-89-5/Intercellular Adhesion Molecule-1; EC 3.4.24.35/MMP9 protein, human; EC 3.4.24.35/Matrix Metalloproteinase 9
Comments/Corrections

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