| Systemic inflammation associated with mechanical ventilation among extremely preterm infants. | |
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MedLine Citation:
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PMID: 23148992 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Little evidence is available to document that mechanical ventilation is an antecedent of systemic inflammation in preterm humans. We obtained blood on postnatal day 14 from 726 infants born before the 28thweek of gestation and measured the concentrations of 25 inflammation-related proteins. We created multivariable models to assess the relationship between duration of ventilation and protein concentrations in the top quartile. Compared to newborns ventilated for fewer than 7days (N=247), those ventilated for 14days (N=330) were more likely to have elevated blood concentrations of pro-inflammatory cytokines (IL-1β, TNF-α), chemokines (IL-8, MCP-1), an adhesion molecule (ICAM-1), and a matrix metalloprotease (MMP-9), and less likely to have elevated blood concentrations of two chemokines (RANTES, MIP-1β), a matrix metalloproteinase (MMP-1), and a growth factor (VEGF). Newborns ventilated for 7-13days (N=149) had systemic inflammation that approximated the pattern of newborns ventilated for 14days. These relationships were not confounded by chorioamnionitis or antenatal corticosteroid exposure, and were not altered appreciably among infants with and without bacteremia. These findings suggest that 2weeks of ventilation are more likely than shorter durations of ventilation to be accompanied by high blood concentrations of pro-inflammatory proteins indicative of systemic inflammation, and by low concentrations of proteins that might protect from inflammation-mediated organ injury. |
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Authors:
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Carl L Bose; Matthew M Laughon; Elizabeth N Allred; T Michael O'Shea; Linda J Van Marter; Richard A Ehrenkranz; Raina N Fichorova; Alan Leviton; |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-10 |
Journal Detail:
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Title: Cytokine Volume: - ISSN: 1096-0023 ISO Abbreviation: Cytokine Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: cbose@med.unc.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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