Document Detail


Systemic inflammation and Alzheimer's Disease.
MedLine Citation:
PMID:  23046210     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
There is a great deal of evidence suggesting an important role for systemic inflammation in the pathogenesis of Alzheimer's Disease. The role of systemic inflammation, and indeed inflammation in general, is still largely considered to be as a contributor to the disease process rather than of aetiological importance although there is emerging evidence to suggest that its role may predate the deposition of amyloid. Therapies aimed at reducing inflammation in individuals with mild cognitive impairment and Alzheimer's Disease have been disappointing and have largely focused on the need to ameliorate central inflammation with little attention to the importance of dampening down systemic inflammation. Novel approaches in this area require a greater understanding of the effects of systemic inflammation on the development and progression of Alzheimer's disease and of the communicating pathways between the systemic and central innate immune systems.
Authors:
Clive Holmes
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-10
Journal Detail:
Title:  Neuropathology and applied neurobiology     Volume:  -     ISSN:  1365-2990     ISO Abbreviation:  Neuropathol. Appl. Neurobiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7609829     Medline TA:  Neuropathol Appl Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author. Neuropathology and Applied Neurobiology © 2012 British Neuropathological Society.
Affiliation:
University of Southampton, Division of Clinical and Experimental Science, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, Southampton, SO43 7AP. ch4@soton.ac.uk.
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