| Systemic and immune manifestations in myelodysplasia: a multicenter retrospective study. | |
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MedLine Citation:
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PMID: 21584947 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The presence of systemic and/or immune manifestations in myelodysplasia has been currently reported. The influence of these manifestations on the natural outcome of myelodysplastic syndrome has to be considered. We present a multicenter retrospective study (2002-2009) of patients with myelodysplastic syndrome disclosing systemic and/or immune manifestations. METHODS: Forty-six patients with myelodysplasia presenting with systemic and/or immune manifestations were compared in terms of survival with 189 patients with myelodysplasia lacking these features. RESULTS: The clinical picture in these cases consisted of fever (13%), arthralgia or arthritis (13%), and cutaneous manifestations (67%). Four cases of systemic vasculitis have been reported in our series, and they have a worse prognosis. Immune anomalies were recorded in 29% of the cases, and the presence of cryoglobulins was also associated with a worse prognosis. CONCLUSION: A difference in survival between patients with myelodysplastic syndrome with systemic manifestations and patients lacking these manifestations has been observed in the presence of systemic vasculitis and/or cryoglobulins. |
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Authors:
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A de Hollanda; A Beucher; D Henrion; A Ghali; C Lavigne; H Lévesque; M Hamidou; J F Subra; N Ifrah; C Belizna |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: Arthritis care & research Volume: 63 ISSN: 2151-4658 ISO Abbreviation: Arthritis Care Res (Hoboken) Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-02 Completed Date: 2011-10-03 Revised Date: 2011-12-09 |
Medline Journal Info:
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Nlm Unique ID: 101518086 Medline TA: Arthritis Care Res (Hoboken) Country: United States |
Other Details:
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Languages: eng Pagination: 1188-94 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 by the American College of Rheumatology. |
Affiliation:
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Internal Medicine Department, University Hospital Angers, 4 rue Larrey, Angers, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Arthralgia / complications, immunology Arthritis / complications, immunology Cryoglobulins / immunology* Female Fever / complications, immunology Humans Longitudinal Studies Male Middle Aged Myelodysplastic Syndromes / complications, immunology* Retrospective Studies Systemic Vasculitis / complications*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Cryoglobulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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