Document Detail

Systemic and immune manifestations in myelodysplasia: a multicenter retrospective study.
MedLine Citation:
PMID:  21584947     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The presence of systemic and/or immune manifestations in myelodysplasia has been currently reported. The influence of these manifestations on the natural outcome of myelodysplastic syndrome has to be considered. We present a multicenter retrospective study (2002-2009) of patients with myelodysplastic syndrome disclosing systemic and/or immune manifestations.
METHODS: Forty-six patients with myelodysplasia presenting with systemic and/or immune manifestations were compared in terms of survival with 189 patients with myelodysplasia lacking these features.
RESULTS: The clinical picture in these cases consisted of fever (13%), arthralgia or arthritis (13%), and cutaneous manifestations (67%). Four cases of systemic vasculitis have been reported in our series, and they have a worse prognosis. Immune anomalies were recorded in 29% of the cases, and the presence of cryoglobulins was also associated with a worse prognosis.
CONCLUSION: A difference in survival between patients with myelodysplastic syndrome with systemic manifestations and patients lacking these manifestations has been observed in the presence of systemic vasculitis and/or cryoglobulins.
A de Hollanda; A Beucher; D Henrion; A Ghali; C Lavigne; H Lévesque; M Hamidou; J F Subra; N Ifrah; C Belizna
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Arthritis care & research     Volume:  63     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-02     Completed Date:  2011-10-03     Revised Date:  2011-12-09    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1188-94     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 by the American College of Rheumatology.
Internal Medicine Department, University Hospital Angers, 4 rue Larrey, Angers, France.
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MeSH Terms
Aged, 80 and over
Arthralgia / complications,  immunology
Arthritis / complications,  immunology
Cryoglobulins / immunology*
Fever / complications,  immunology
Longitudinal Studies
Middle Aged
Myelodysplastic Syndromes / complications,  immunology*
Retrospective Studies
Systemic Vasculitis / complications*,  immunology
Reg. No./Substance:

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