| Systemic hypertension in two patients with ASL deficiency: a result of nitric oxide deficiency? | |
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MedLine Citation:
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PMID: 19592285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Argininosuccinic aciduria (ASA) is an inborn error of ureagenesis which if untreated leads to hyperammonemia, accumulation of argininosuccinic acid and arginine depletion. The presence of high blood pressure in patients with ASA has been reported so far as transient in one newborn. We describe the first two patients, one child and one young adult, with ASA and persistent systemic hypertension. Extensive evaluation of both patients excluded secondary causes of systemic hypertension. The intriguing link between nitric oxide (NO) production and hypertension lead us to hypothesize that the deficiency of endogenously synthesized arginine caused by ASL deficiency is responsible for the increased blood pressure. |
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Authors:
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Nicola Brunetti-Pierri; Ayelet Erez; Oleg Shchelochkov; William Craigen; Brendan Lee |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-06-13 |
Journal Detail:
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Title: Molecular genetics and metabolism Volume: 98 ISSN: 1096-7206 ISO Abbreviation: Mol. Genet. Metab. Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2009-11-05 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9805456 Medline TA: Mol Genet Metab Country: United States |
Other Details:
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Languages: eng Pagination: 195-7 Citation Subset: IM |
Affiliation:
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Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Argininosuccinic Aciduria* Child Child, Preschool Female Humans Hypertension / enzymology* Infant, Newborn Male Nitric Oxide / deficiency* |
| Grant Support | |
ID/Acronym/Agency:
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DK54450/DK/NIDDK NIH HHS; HD024064/HD/NICHD NIH HHS; HD041648/HD/NICHD NIH HHS; R01 DK054450-10/DK/NIDDK NIH HHS; RR00188/RR/NCRR NIH HHS; RR019453/RR/NCRR NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
| Comments/Corrections | |
Comment In:
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Mol Genet Metab. 2010 Apr;99(4):438
[PMID:
20036174
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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