Document Detail

Systemic hemodynamic pattern in primary hyperparathyroidism and its changes after parathyroidectomy.
MedLine Citation:
PMID:  1779935     Owner:  NLM     Status:  MEDLINE    
Twelve patients (7 men and 5 women) with an average age of 53 years (range 37-69) were hospitalized for renal stones and found to have primary hyperparathyroidism. Five were hypertensive and 7 normotensive. The systemic hemodynamics, plasma renin activity and glomerular filtration rate were evaluated before and at least 6 months after removal of a parathyroid adenoma. After surgery the mean intra-arterial blood pressure fell in almost all patients, due to some reduction in the peripheral vascular resistance index with no change in the cardiac index. However, the hemodynamic variations were not uniform in all patients. No change was seen in plasma renin activity and glomerular filtration rate. A positive correlation between the percent change in mean arterial pressure and percent decrease in total serum calcium was found. The results obtained indicate that it is likely that hypercalcemia plays some role both in patients with high and those with normal blood pressure. The systemic hemodynamic changes after parathyroidectomy indicate that the fall in peripheral vascular resistance could have a certain influence.
E Valvo; V Bedogna; L Gammaro; P Casagrande; V Ortalda; G Maschio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mineral and electrolyte metabolism     Volume:  17     ISSN:  0378-0392     ISO Abbreviation:  Miner Electrolyte Metab     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-09     Completed Date:  1992-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802196     Medline TA:  Miner Electrolyte Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
Divisione di Nefrologia, Istituti Ospitalieri, Verona, Italy.
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MeSH Terms
Blood Pressure*
Calcium / blood*
Glomerular Filtration Rate
Hyperparathyroidism / etiology,  physiopathology*,  surgery
Kidney Calculi / complications
Middle Aged
Renin / blood
Vascular Resistance
Reg. No./Substance:
7440-70-2/Calcium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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