Document Detail

Systemic hemodynamic, forearm vascular, renal, and humoral responses to sustained cardiopulmonary baroreceptor deactivation in well-compensated cirrhosis.
MedLine Citation:
PMID:  7875669     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to assess baroreceptor function in well-compensated cirrhosis by determining the forearm vascular, renal, and humoral responses to sustained baroreceptor deactivation. The effect of sodium status on baroreceptor function was also assessed. Eight cirrhotic patients and 10 age- and sex-matched controls were studied twice after a 20 mmol and 200 mmol of sodium/d diet for 7 days. Systemic and renal hemodynamics, renal sodium handling, forearm blood flow, and neurohumoral factors were assessed before, during, and after the application of lower body negative pressure (LBNP) for 1 hour. Controls and cirrhotic patients had similar baseline mean arterial pressure, heart rate, forearm and renal hemodynamics. High-sodium intake resulted in suppression of sympathetic nervous activity in the controls (plasma norepinephrine, 1.06 +/- 0.11 nmol/L on low vs. 0.76 +/- 0.08 nmol/L on high sodium; P = 0.01) but not in the cirrhotic patients (1.35 +/- 0.22 nmol/L on low vs. 1.26 +/- 0.11 nmol/L on high sodium; P > 0.05). Both groups responded to LBNP with significant further increases in plasma norepinephrine, resulting in significant decreases in forearm blood flow on both sodium diets. Controls also responded with a significant worsening of renal hemodynamics on low-sodium diet only, but this was not observed in the cirrhotic patients on either diet. Therefore, in well-compensated cirrhotic patients: (1) sympathetic activation occurs despite an adequate, effective arterial filling, and this may contribute to sodium retention; and (2) baroreceptor function is normal. Apparent end organ unresponsiveness within the renal circulation may account for the lack of renal hemodynamic changes to reflex sympathetic stimulation.
F Wong; A Logan; L Blendis
Related Documents :
1128229 - Relationships of the renin-angiotensin-aldosterone system and sodium balance to blood p...
15821419 - Can dietary changes reduce blood pressure in the long term?
8731109 - Urinary kallikrein: a marker of blood pressure sensitivity to salt.
6654449 - Hemodynamic mechanisms of adaptation to chronic high sodium intake in normal humans.
3241259 - Effect of potassium supplementation combined with dietary sodium reduction on blood pre...
3716879 - Body composition, intraerythrocyte sodium content, volume regulation and blood pressure...
7913949 - Nutritional dose of magnesium in hypertensive patients on beta blockers lowers systolic...
24197679 - Circulating obestatin levels correlate with fasting insulin and homa-ir but not with hy...
6427499 - Open-loop analysis of paco2 oscillation in the dog.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  21     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-04-04     Completed Date:  1995-04-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  717-24     Citation Subset:  IM; S    
Department of Medicine, Toronto Hospital, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Vessels / physiopathology
Diet, Sodium-Restricted
Forearm / blood supply*
Heart Conduction System / physiopathology
Hormones / blood*
Kidney / physiopathology*
Liver Cirrhosis / physiopathology*
Lower Body Negative Pressure
Lung / innervation
Middle Aged
Pressoreceptors / physiopathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Transjugular intrahepatic portosystemic shunts for refractory ascites: assessment of clinical and ho...
Next Document:  Prevalence, severity, and risk factors of liver disease in blood donors positive in a second-generat...