| Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial. | |
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MedLine Citation:
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PMID: 12619027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study is to evaluate the effect of a single treatment with the molecular adsorbents recirculating system (MARS) on systemic hemodynamics and oxygen consumption (VO(2)) in patients with hyperacute liver failure (HALF). In a controlled design, eight patients with HALF were assigned to a 6-hour MARS treatment, and five patients, to a control group that was mechanically cooled to match the MARS group. Systemic hemodynamic variables were determined hourly during the study period. In the MARS group, systemic vascular resistance index increased by 46% from 1,215 +/- 437 to 1,778 +/- 710 dynes x s x cm(-5) x m(-2) (P <.0001), which significantly exceeded a 6% increase in the control group. Mean arterial pressure increased from 69 +/- 5 to 83 +/- 11 mm Hg in the MARS group (P <.0001) and was unchanged in the control group. Cardiac index decreased by 20% from 4.6 +/- 1.8 to 3.7 +/- 1.1 L/min x m(-2) (P =.0007) in the MARS group and by 7% in the control group. Heart rate decreased from 105 +/- 21 to 85 +/- 15 beats/min in the MARS group (P <.0001) and was unchanged in the control group. In the MARS group, oxygen delivery decreased from 621 +/- 198 to 486 +/- 141 mL/min x m(-2) (P <.05), and VO2, from 142 +/- 31 to 112 +/-21 mL/min x m(-2) (P <.05). Arterial lactate and pH levels were unchanged. In conclusion, systemic hemodynamic values tend to normalize, whereas systemic VO(2) decreases during MARS treatment in patients with HALF. These effects cannot be explained by the degree of cooling associated with MARS. |
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Authors:
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Lars E Schmidt; Lars Peter Wang; Bent A Hansen; Fin Stolze Larsen |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Volume: 9 ISSN: 1527-6465 ISO Abbreviation: Liver Transpl. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-05 Completed Date: 2003-09-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 100909185 Medline TA: Liver Transpl Country: United States |
Other Details:
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Languages: eng Pagination: 290-7 Citation Subset: IM |
Affiliation:
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Department of Hepatology, Rigshospitalet, University Hospital, Copenhagen, Denmark. lars.schmidt@dadlnet.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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poisoning Adult Alcohol Deterrents / poisoning Analgesics, Non-Narcotic / poisoning Blood Pressure Disulfiram / poisoning Drug-Induced Liver Injury / therapy Female Heart Rate Hepatitis B / therapy Humans Liver Failure, Acute / therapy* Male Middle Aged Oxygen / blood Prospective Studies Pulmonary Wedge Pressure Sorption Detoxification* Temperature Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Alcohol Deterrents; 0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen; 7782-44-7/Oxygen; 97-77-8/Disulfiram |
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