Document Detail


Systemic hantavirus-infection in a comatose HIV patient.
MedLine Citation:
PMID:  23341221     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SYMPTOMS: A 40 year old, disoriented, HIV- and Hepatitis B positive male patient was admitted with 40.3 °C. Clinically he presented a sinustachycardia (160/min) and hypotension (70/60 mmHg). INVESTIGATIONS/DIAGNOSIS: Laboratory analyses showed elevated infection parameters, azotemia, proteinuria and thrombopenia. CD(4+)T-helper cells: 320/µl (32 %), HIV RNA: < 40 copies/ml, Hepatitis B DNA: 20800 copies/ml. Hantavirus serology (immunofluorescence antibody assay): 1:2048; serotype Puumala. TREATMENT/COURSE: An early-goal-directed therapy and antibiotic treatment with Piperacillin and Tazobactam was initiated. The patient developed a bipulmonal infiltrate and an acute respiratory distress syndrome (ARDS ) requiring tracheal intubation, as well as a triad of fever, renal failure and profound hemorrhagic symptoms. This led to the diagnosis of the Puumala infection. Due to the parallel HIV- and Hepatits B infection an antiretroviral therapy was initiated. CONCLUSION: In summary the Puumala infection bears the potential for a severe multi-organ failure, which is not typical for this usually benign infection.
Authors:
Robert Larbig; Clara Lehman; Dennis Rottländer; Sara Reda; Guido Michels; Uta C Hoppe; Mathias Kochanek
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Wiener medizinische Wochenschrift (1946)     Volume:  -     ISSN:  1563-258X     ISO Abbreviation:  Wien Med Wochenschr     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708475     Medline TA:  Wien Med Wochenschr     Country:  -    
Other Details:
Languages:  GER     Pagination:  -     Citation Subset:  -    
Affiliation:
Universitätsklinik II für Innere Medizin, Paracelsus Medizinische Universität Salzburg, Müllner Hauptstrasse 48, 5020, Salzburg, Österreich, r.larbig@salk.at.
Vernacular Title:
Systemische Hantavirus-Infektion bei einem komatösen HIV Patienten.
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