Document Detail

Systemic fungal infection in very low-birth-weight infants.
MedLine Citation:
PMID:  8854349     Owner:  NLM     Status:  MEDLINE    
This retrospective study was designed to investigate the related factors and outcome of systemic fungal infection in very low-birth-weight (VLBW) infants. Medical records of infants admitted to the neonatal intensive care unit of National Cheng Kung University Hospital between January 1990 and June 1994 were reviewed. Of the 262 VLBW infants, 15 (5.7%) had fungemia (14 Candida 1 Cryptococcus) during the study period. Among the fungemic infants, 60% also had urinary tract infection; 18% had central nervous system infection. Their mean birth weight was 1079 +/- 78 g (504-1474 g), and the gestational age was 28.6 +/- 0.6 weeks (23-32 weeks). Thirteen of them (87%) had respiratory distress syndrome and patent ductus arteriosus, while 60% had chronic lung disease. The percentage of antibiotic usage, parenteral hyperalimentation, endotracheal intubation, placement of central venous line and steroid therapy were 100%, 100%, 73%, 67% and 36% respectively. The mean age at diagnosis of fungemia was 40.5 +/- 4.8 days (10-76 days). Common clinical manifestations were respiratory deterioration (93%), poor feeding (58%) and fever (53%). The frequency of side effects of amphotericin B in decreasing order were: hypokalemia (54%), hyponatremia (31%) and decreased urine amount (23%). The mortality rate was 40%. It was concluded that systemic fungal infection in VLBW infants might result in high mortality and the side effects were high in the treated infants.
L W Wang; C H Lin; C C Liu; Y J Lin
Related Documents :
9745329 - Cytomegalovirus (cmv) in cervical secretion and breast milk. a thirty years perspective.
18444089 - Cortical maldevelopment in congenital cytomegalovirus infection transmitted by a woman ...
6481539 - Systemic candida infections in infants in intensive care nurseries: high incidence of c...
12089249 - Horizontal transmission of candida parapsilosis candidemia in a neonatal intensive care...
11773559 - Infective endocarditis successfully treated in extremely low birth weight infants with ...
18089629 - Group b streptococcal disease in portuguese infants younger than 90 days.
6177239 - Infants with bronchopulmonary dysplasia. growth pattern and neurologic and developmenta...
3288429 - Pulmonary hypertension and persistent fetal circulation in the newborn.
7191639 - Comparative newborn anthropometric data in symmetric versus asymmetric intrauterine gro...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui     Volume:  37     ISSN:  0001-6578     ISO Abbreviation:  Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1996-11-07     Completed Date:  1996-11-07     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  16210470R     Medline TA:  Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  272-7     Citation Subset:  IM    
Department of Pediatrics, Chi-Mei Foundation Hospital, Tainan, Taiwan, R.O.C.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amphotericin B / therapeutic use
Antifungal Agents / therapeutic use
Combined Modality Therapy
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature
Intensive Care, Neonatal
Mycoses / complications,  diagnosis*,  drug therapy,  microbiology
Retrospective Studies
Reg. No./Substance:
0/Antifungal Agents; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Direct tracheobronchial suction for massive post-extubation atelectasis in premature infants.
Next Document:  Risk factors of cholestasis in very low-birth-weight infants.