| Systemic effects of whole-body cooling to 35ºC, 33.5ºC and 30ºC in a piglet perinatal asphyxia model: implications for therapeutic hypothermia. | |
| | |
MedLine Citation:
|
PMID: 22314664 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The precise temperature for optimal neuroprotection in infants with neonatal encephalopathy is unclear. Our aim was to assess systemic effects of whole-body cooling to 35(o)C, 33.5(o)C and 30(o)C in a piglet perinatal asphyxia model. Twenty-eight anesthetised male piglets aged <24h underwent hypoxia-ischemia and randomized to normothermia; or cooling to rectal temperature (Trec) 35(o)C, 33.5(o)C, or 30(o)C during 2-26 h post insult (groups n=7). Heart rate (HR), mean arterial blood pressure (MABP) and Trec were recorded continuously. Five 30(o)C animals had fatal cardiac arrests. During 30(o)C cooling HR was lower vs normothermia (p<0.001). Although MABP did not vary between groups, more fluid boluses were needed at 30(o)C than normothermia (p<0.02); dopamine use was higher at 30(o)C than normothermia and 35(o)C (p=0.005, p=0.02). Base deficit was increased at 30(o)C at 12,24 and 36h vs all other groups (p<0.05), pH was acidotic at 36h vs normothermia (p=0.04) and blood glucose higher for 30(o)C at 12h vs normothermia and 35(o)C (p<0.05). Potassium was lower at 12h in the 30(o)C group vs 33.5(o)C and 35(o)C groups. Cortisol was no different between groups. Cooling to 30(o)C led to metabolic derangement, more cardiac arrests and deaths than cooling to 33.5(o)C or 35(o)C. Inadvertent overcooling should be avoided. |
| | |
Authors:
|
Aron Kerenyi; Dorottya Kelen; Stuart D Faulkner; Alan Bainbridge; Manigandan Chandrasekaran; Ernest B Cady; Xavier Golay; Nicola J Robertson |
Related Documents
:
|
2676954 - Diaphragmatic plate electrode stimulation of the hamster diaphragm. 22505644 - Differential impact of short periods of rapid atrial pacing on left and right atrial me... 2494694 - Papillary function of patients with juxtapapillary duodenal diverticulum. consideration... 2880594 - Cardiovascular effect of sparteine in anaesthetized dogs with and without blockade of c... 572044 - Risk and advantages of using strongly beveled microelectrodes for electrophysiological ... 20216174 - Pressure-created communication between lumens of a multilumen venous catheter. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-07 |
Journal Detail:
|
Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Institute for Women's Health (AK, DK, SDF, MC, NJR), University College London, London WCIE 6AU, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Infection of Pregnant Mice with Listeria monocytogenes Induces Fetal Bradycardia.
Next Document: Organizational Justice and Psychological Distress Among Permanent and Non-permanent Employees in Jap...