Document Detail


Systemic effects of carteolol, a beta-adrenoceptor antagonist in stroke-prone spontaneously hypertensive rats.
MedLine Citation:
PMID:  1971305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The preventive effects of carteolol, a beta-adrenoceptor antagonist, on secondary lesions were pathophysiologically examined in stroke-prone spontaneously hypertensive rats (SHRSP) from 8 to 30 weeks of age. Carteolol was added to the drinking water in doses of 0.005% (8 to 18 weeks of age) to 0.01% (19 to 30 weeks of age) (3.8 and 6.0 mg/kg/d, respectively). These animals gained significantly more weight than the untreated control SHRSP, and their heart rate reduced from 14 weeks of age. Suppression of blood pressure rise was not definite, however, histology revealed prevention of the development or aggravation of secondary hypertension-related lesions, such as myocardial fibrosis, proliferative arteriolitis, necrotic arteriolitis and renal glomerular lesions. A decrease in non-esterified fatty acids in the serum was evident. Thus, carteolol has cardiac as well as renal protective effects, in the SHRSP.
Authors:
K Yamashita; H Ohta; S Uchida; K Shigematsu; T Ohkubo; M Niwa; M Ozaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacobio-dynamics     Volume:  13     ISSN:  0386-846X     ISO Abbreviation:  J. Pharmacobio-dyn.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-06-28     Completed Date:  1990-06-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7901854     Medline TA:  J Pharmacobiodyn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  64-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology 2, Nagasaki University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / pathology
Adrenergic beta-Antagonists / pharmacology
Animals
Aorta, Abdominal / pathology
Blood Pressure / drug effects*
Blood Urea Nitrogen
Body Weight / drug effects
Brain / pathology
Carteolol / pharmacology*
Fatty Acids, Nonesterified / blood
Heart Rate / drug effects
Kidney / pathology
Liver / pathology
Lung / pathology
Male
Mesentery / pathology
Myocardium / pathology
Organ Size / drug effects
Propanolamines / pharmacology*
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Spleen / pathology
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Fatty Acids, Nonesterified; 0/Propanolamines; 0/Triglycerides; 51781-06-7/Carteolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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