| Systemic effects associated with intermittent claudication. A model to study biochemical aspects of vascular disease? | |
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MedLine Citation:
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PMID: 3253123 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with intermittent claudication were used as a clinical model to study the effects of transient episodes of ischaemia. Compared with age and sex matched controls significantly greater increases in serum lipid peroxides and urinary microalbumin occurred after exercise. These results suggest that even relatively minor ischaemic episodes, as occur with claudication, are sufficient to cause tissue damage which may be mediated by oxygen derived free radicals. There are also changes in renal permselectivity suggestive of a generalised increase in vascular permeability. These preliminary findings may have important diagnostic, aetiological and therapeutic implications for patients with vascular disease. |
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Authors:
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C P Shearman; P Gosling; B R Gwynn; M H Simms |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of vascular surgery Volume: 2 ISSN: 0950-821X ISO Abbreviation: Eur J Vasc Surg Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-08-25 Completed Date: 1989-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709440 Medline TA: Eur J Vasc Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 401-4 Citation Subset: IM |
Affiliation:
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Department of Surgery, Selly Oak Hospital, Birmingham, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Albuminuria / urine Capillary Permeability Female Humans Intermittent Claudication / blood, metabolism*, urine Lipid Peroxides / blood* Male Middle Aged Models, Biological |
| Chemical | |
Reg. No./Substance:
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0/Lipid Peroxides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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