Document Detail

Systemic effects associated with intermittent claudication. A model to study biochemical aspects of vascular disease?
MedLine Citation:
PMID:  3253123     Owner:  NLM     Status:  MEDLINE    
Patients with intermittent claudication were used as a clinical model to study the effects of transient episodes of ischaemia. Compared with age and sex matched controls significantly greater increases in serum lipid peroxides and urinary microalbumin occurred after exercise. These results suggest that even relatively minor ischaemic episodes, as occur with claudication, are sufficient to cause tissue damage which may be mediated by oxygen derived free radicals. There are also changes in renal permselectivity suggestive of a generalised increase in vascular permeability. These preliminary findings may have important diagnostic, aetiological and therapeutic implications for patients with vascular disease.
C P Shearman; P Gosling; B R Gwynn; M H Simms
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of vascular surgery     Volume:  2     ISSN:  0950-821X     ISO Abbreviation:  Eur J Vasc Surg     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709440     Medline TA:  Eur J Vasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  401-4     Citation Subset:  IM    
Department of Surgery, Selly Oak Hospital, Birmingham, U.K.
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MeSH Terms
Albuminuria / urine
Capillary Permeability
Intermittent Claudication / blood,  metabolism*,  urine
Lipid Peroxides / blood*
Middle Aged
Models, Biological
Reg. No./Substance:
0/Lipid Peroxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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