Document Detail

Systemic contact dermatitis from propylene glycol.
MedLine Citation:
PMID:  18413114     Owner:  NLM     Status:  MEDLINE    
A 39-year-old woman presented with pruritic eczematous plaques on her face, neck, and right hand that she had had for approximately 2 months, following an abrasive injury caused by the deployment of an airbag in a car accident. Results of patch testing were positive for several medicaments and propylene glycol (PG). The patient's condition cleared after discontinuation of all topical products containing PG and her other identified allergens, but she noted flares of her contact dermatitis following the ingestion of foods containing PG. A subset of patients will have a recurrence of dermatitis after the ingestion of a contact sensitizer. Recurrent dermatitis despite complete avoidance of identified topical allergens and a history of recurrent eczema at the patch-test site are clues to the diagnosis of systemic contact dermatitis. Even weak patch reactions to PG, if they persist to a day-7 reading, should be considered potentially relevant. Avoidance of dietary PG includes attention to labels on food and medication and the avoidance of certain foods in restaurants when ingredients cannot be verified.
Abigail Lowther; Thomas McCormick; Susan Nedorost
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Dermatitis : contact, atopic, occupational, drug     Volume:  19     ISSN:  1710-3568     ISO Abbreviation:  Dermatitis     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-04-16     Completed Date:  2008-08-07     Revised Date:  2013-08-30    
Medline Journal Info:
Nlm Unique ID:  101207335     Medline TA:  Dermatitis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  105-8     Citation Subset:  IM    
University Hospitals Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
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MeSH Terms
Cosmetics / adverse effects*
Dermatitis, Allergic Contact / diagnosis,  etiology*
Dermatologic Agents / adverse effects*
Erythema / drug therapy
Food / adverse effects*
Patch Tests
Propylene Glycol / adverse effects*
Skin / pathology
Reg. No./Substance:
0/Cosmetics; 0/Dermatologic Agents; 57-55-6/Propylene Glycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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