| Systemic changes in haemostatic balance are not associated with increased levels of circulating microparticles in women with recurrent spontaneous abortion. | |
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MedLine Citation:
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PMID: 18211541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: Placental fibrin deposits in patients wih recurrent spontaneous abortion (RSA) indicate an exaggerated haemostatic response. This 'hypercoagulability' may involve pro-coagulant factors such as circulating microparticles (MPs). We investigated the relationship between circulating pro-coagulant MPs and systemic coagulation in RSA patients. METHOD OF STUDY: Platelet- and endothelial cell-derived microparticles (PMPs, EMPs) were evaluated by flow cytometry in RSA patients (n = 51) and compared to controls (n = 24) using annexin V (total numbers of MP), and antibodies against CD61, CD63 and CD62P (PMP), as well as CD144 and CD62E (EMP). Prothrombin fragment 1 + 2 (F(1+2)) and thrombin generation were determined to assess the pro-coagulant potential of MP. RESULTS: Numbers of annexin V-binding MP were nearly similar in RSA patients and controls. However, a subgroup of ten RSA patients (10/51; 20%) presented with MP concentrations >10,000 x 10(6)/L, compared to only one women out of the control group (1/24; 4%; P = 0.038). Neither PMP and EMP nor F(1+2) and thrombin generation differed significantly within the study population. CONCLUSION: The present study shows that circulating MPs are not directly associated with the extent of systemic coagulation activation in RSA patients. We hypothesize that increased numbers of circulating MPs either are only indirectly associated with coagulation during pregnancy of RSA patients, or affect abortion via mechanisms independently from hypercoagulation. |
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Authors:
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Bettina Toth; Rienk Nieuwland; Meike Kern; Nina Rogenhofer; René Berkmans; Andreas Rank; Peter Lohse; Klaus Friese; Christian J Thaler |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 59 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-23 Completed Date: 2008-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 159-66 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology-Grosshadern, Ludwig-Maximilians-University, Munich, Germany. bettina.toth@med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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blood* Adult Blood Coagulation Blood Coagulation Factors / metabolism* Blood Platelets / physiology Case-Control Studies Endothelial Cells / physiology Female Flow Cytometry Hemostasis Humans Peptide Fragments / blood Prospective Studies Prothrombin Statistics, Nonparametric Thrombin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors; 0/Peptide Fragments; 0/prothrombin fragment 1.2; 9001-26-7/Prothrombin; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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