Document Detail

Systemic baroreflex alterations in prehepatic portal hypertensive conscious rats.
MedLine Citation:
PMID:  8548476     Owner:  NLM     Status:  MEDLINE    
In portal hypertensive patients and experimental models, hyperdynamic circulatory disturbances associated to a reduced peripheral resistance and an increased cardiac output appeared. The aim of this research is the study of the baroreflex system behavior partially portal vein ligated-portal hypertensive rats. Sham operated rats (S) (n = 7) and portal hypertensive rats (PH) (n = 9) were used. In anesthetized rats, catheters were introduced into a jugular vein for drug injection and into the ventral tail artery to record blood pressure and heart rate. When rats were conscious and moving freely, a bolus injection of phenylephrine hydrochloride (6 micrograms/kg) was injected in the vein. A sigmoid curve relating systolic blood pressure and heart period was dressed. We analyzed: 1) The gain or sensitivity: the slope of the regression line; 2) The threshold: systolic blood pressure at which the regression begins to be linear. The results were: mean arterial pressure (mmHg): S = 103 +/- 7; PH = 109 +/- 3; gain (ms/mmHg): S = 1.29 +/- 0.10; PH = 0.62 +/- 0.04 (p < 0.001); threshold (mmHg): S = 145 +/- 7; PH = 146 +/- 4. The baroreceptor reflex sensitivity was significantly decreased. No differences appeared in the mean arterial pressure and in the reflex threshold. It is suggested that portal hypertension induces alterations in baroreflex regulation of arterial blood pressure.
C T Arranz; A M Balaszczuk; M A Costa; F X Eizayaga; S Romay; C Mongelli; A Lemberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of physiology and biochemistry     Volume:  103     ISSN:  1381-3455     ISO Abbreviation:  Arch. Physiol. Biochem.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-02-22     Completed Date:  1996-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9510153     Medline TA:  Arch Physiol Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  422-6     Citation Subset:  IM    
Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
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MeSH Terms
Baroreflex / physiology*
Blood Pressure / physiology
Disease Models, Animal
Hypertension, Portal / physiopathology*
Linear Models
Portal Vein
Rats, Wistar

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