Document Detail

Systemic arterial inflammation, measured with (18)FDG-PET, is common amongst subjects with both recent and prior cerebrovascular disease.
MedLine Citation:
PMID:  22226631     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To compare systemic arterial inflammation in subjects with recent ischaemic stroke or TIA and controls with prior cerebrovascular disease. METHODS: Systemic arterial inflammation was prospectively measured by (18)F-fluorodeoxygluose positron emission tomography in 11 cases with recent ischaemic stroke or TIA, and 11 sex matched controls with prior cerebrovascular disease. RESULTS: Hot spots (both carotid and non-carotid) of localised (18)FDG uptake were found in more than half of all patients with either recent (n=6) or prior (n=8) cerebrovascular disease. There was no significant difference in the total number of hotspots, or hotspots at specific sites, in cases compared with controls. Mean standard uptake values (SUV) were similar in the carotid arteries and aorta of cases and controls, and showed a trend toward higher values in the femoral arteries of the controls (median 1.8; IQR 1.6-2.2) compared to cases (median 1.5; IQR 1.4-1.7). CONCLUSION: Arterial inflammation was common, and appeared similar, in patients with recent stroke/TIA, and controls with stroke/TIA more than two years previously.
Christopher D Beer; Kathleen Potter; Nat Lenzo; David Blacker; Leonard F Arnolda; Graeme J Hankey; Ian B Puddey
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-5
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  -     ISSN:  1872-6968     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Western Australian Centre for Health & Ageing, University of Western Australia, Australia; School of Medicine and Pharmacology, University of Western Australia, Australia; Centre for Medical Research, Western Australian Institute for Medical Research, Australia; Royal Perth Hospital, Perth, Australia.
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