Document Detail


Systemic and arterial hemodynamic effects of nifedipine (20 mg) in mild-to-moderate hypertension.
MedLine Citation:
PMID:  6654465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systemic and arterial hemodynamic effects of the new 20 mg tablet of nifedipine were studied in seven patients with mild-to-moderate essential hypertension. Hemodynamics of the forearm arterial circulation were investigated using a new pulsed Doppler system, enabling the simultaneous determination of the brachial artery diameter and the arterial blood flow velocity. After nifedipine administration, blood pressure decreased significantly, due to a fall in total peripheral resistance. Simultaneously, brachial blood flow increased significantly, due both to an increase in arterial diameter and blood flow velocity. The study provided evidence that, with nifedipine, there is both 1) a dilation of small arteries, causing a decrease in blood pressure; and 2) a dilation of peripheral large arteries, leading to an increase in peripheral blood flow.
Authors:
J A Levenson; M E Safar; A C Simon; J A Boutier; L Griener
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  5     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1983 Nov-Dec
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  V57-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Circulation / drug effects
Blood Flow Velocity
Blood Pressure / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Hypertension / drug therapy*,  physiopathology
Male
Middle Aged
Nifedipine / administration & dosage,  pharmacology*
Ultrasonography
Vascular Resistance / drug effects
Vasodilation / drug effects
Chemical
Reg. No./Substance:
21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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