| Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease. | |
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MedLine Citation:
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PMID: 12692003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Coronary artery aneurysms are the major complication of Kawasaki disease (KD). Matrix metalloproteinases (MMPs) regulate remodeling and degradation of the extracellular matrix. We hypothesized that MMP-9 expression is increased in acute KD aneurysms when compared with KD nonaneurysmal arteries and arteries from control children. METHODS AND RESULTS: MMP-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1, and TIMP-2 were immunolocalized in coronary arteries from children with fatal acute KD and controls. In KD coronary aneurysms, MMP-2 expression was prominent in the thickened neointima and in endothelial cells of new capillaries in areas of angiogenesis. MMP-9 was absent in control coronary arteries but was expressed in coronary artery aneurysms, nonaneurysmal coronary and noncoronary arteries, and cardiac nerves in acute KD, without an increase in TIMP-1 expression. CONCLUSIONS: MMP-2 likely participates in remodeling of the arterial wall in acute KD, particularly in the processes of neointimal proliferation and angiogenesis. MMP-9 may play a role in the development of coronary aneurysms, but its expression is not confined to aneurysmal arteries. Systemic arterial expression of MMP-9 in acute KD, even in the absence of inflammatory changes in the vessel, suggests induction by a circulating factor, or possibly by an infectious agent with tropism for arterial tissue. |
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Authors:
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Patrick J Gavin; Susan E Crawford; Stanford T Shulman; Francesca L Garcia; Anne H Rowley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2003-03-06 |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 23 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-14 Completed Date: 2004-01-15 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 576-81 Citation Subset: IM |
Affiliation:
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Division of Infectious Disease, Children's Memorial Hospital, Chicago, Ill, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Child Coronary Aneurysm / enzymology, etiology Coronary Vessels / chemistry, enzymology*, pathology Elastin / analysis Enzyme Induction Female Humans Male Matrix Metalloproteinase 2 / analysis* Matrix Metalloproteinase 9 / analysis* Mucocutaneous Lymph Node Syndrome / complications, enzymology* Muscle, Smooth, Vascular / enzymology Myocardium / enzymology Tissue Inhibitor of Metalloproteinase-1 / analysis Tissue Inhibitor of Metalloproteinase-2 / analysis Tunica Intima / enzymology |
| Grant Support | |
ID/Acronym/Agency:
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HL 03270/HL/NHLBI NIH HHS; HL 63771/HL/NHLBI NIH HHS; K02 HL067011-04/HL/NHLBI NIH HHS; R01 HL063771-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tissue Inhibitor of Metalloproteinase-1; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; 9007-58-3/Elastin; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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