Document Detail


Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease.
MedLine Citation:
PMID:  12692003     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Coronary artery aneurysms are the major complication of Kawasaki disease (KD). Matrix metalloproteinases (MMPs) regulate remodeling and degradation of the extracellular matrix. We hypothesized that MMP-9 expression is increased in acute KD aneurysms when compared with KD nonaneurysmal arteries and arteries from control children. METHODS AND RESULTS: MMP-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1, and TIMP-2 were immunolocalized in coronary arteries from children with fatal acute KD and controls. In KD coronary aneurysms, MMP-2 expression was prominent in the thickened neointima and in endothelial cells of new capillaries in areas of angiogenesis. MMP-9 was absent in control coronary arteries but was expressed in coronary artery aneurysms, nonaneurysmal coronary and noncoronary arteries, and cardiac nerves in acute KD, without an increase in TIMP-1 expression. CONCLUSIONS: MMP-2 likely participates in remodeling of the arterial wall in acute KD, particularly in the processes of neointimal proliferation and angiogenesis. MMP-9 may play a role in the development of coronary aneurysms, but its expression is not confined to aneurysmal arteries. Systemic arterial expression of MMP-9 in acute KD, even in the absence of inflammatory changes in the vessel, suggests induction by a circulating factor, or possibly by an infectious agent with tropism for arterial tissue.
Authors:
Patrick J Gavin; Susan E Crawford; Stanford T Shulman; Francesca L Garcia; Anne H Rowley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-03-06
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  23     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-14     Completed Date:  2004-01-15     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  576-81     Citation Subset:  IM    
Affiliation:
Division of Infectious Disease, Children's Memorial Hospital, Chicago, Ill, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Child
Coronary Aneurysm / enzymology,  etiology
Coronary Vessels / chemistry,  enzymology*,  pathology
Elastin / analysis
Enzyme Induction
Female
Humans
Male
Matrix Metalloproteinase 2 / analysis*
Matrix Metalloproteinase 9 / analysis*
Mucocutaneous Lymph Node Syndrome / complications,  enzymology*
Muscle, Smooth, Vascular / enzymology
Myocardium / enzymology
Tissue Inhibitor of Metalloproteinase-1 / analysis
Tissue Inhibitor of Metalloproteinase-2 / analysis
Tunica Intima / enzymology
Grant Support
ID/Acronym/Agency:
HL 03270/HL/NHLBI NIH HHS; HL 63771/HL/NHLBI NIH HHS; K02 HL067011-04/HL/NHLBI NIH HHS; R01 HL063771-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Tissue Inhibitor of Metalloproteinase-1; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; 9007-58-3/Elastin; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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