Document Detail

Systemic approaches to biodegradation.
MedLine Citation:
PMID:  19054119     Owner:  NLM     Status:  MEDLINE    
Biodegradation, the ability of microorganisms to remove complex chemicals from the environment, is a multifaceted process in which many biotic and abiotic factors are implicated. The recent accumulation of knowledge about the biochemistry and genetics of the biodegradation process, and its categorization and formalization in structured databases, has recently opened the door to systems biology approaches, where the interactions of the involved parts are the main subject of study, and the system is analysed as a whole. The global analysis of the biodegradation metabolic network is beginning to produce knowledge about its structure, behaviour and evolution, such as its free-scale structure or its intrinsic robustness. Moreover, these approaches are also developing into useful tools such as predictors for compounds' degradability or the assisted design of artificial pathways. However, it is the environmental application of high-throughput technologies from the genomics, metagenomics, proteomics and metabolomics that harbours the most promising opportunities to understand the biodegradation process, and at the same time poses tremendous challenges from the data management and data mining point of view.
Almudena Trigo; Alfonso Valencia; Ildefonso Cases
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-11-13
Journal Detail:
Title:  FEMS microbiology reviews     Volume:  33     ISSN:  0168-6445     ISO Abbreviation:  FEMS Microbiol. Rev.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902526     Medline TA:  FEMS Microbiol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  98-108     Citation Subset:  IM    
Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre, Madrid, Spain.
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MeSH Terms
Bacteria / genetics,  metabolism*
Biodegradation, Environmental
Metabolic Networks and Pathways
Protein Interaction Mapping
Systems Biology*

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