Document Detail

Systemic angiotensin II acts at the subfornical organ to suppress voluntary alcohol consumption.
MedLine Citation:
PMID:  2626449     Owner:  NLM     Status:  MEDLINE    
The subfornical organ plays a role in a number of the effects of blood-borne angiotensin II (ANG II) including the increase in water drinking and blood pressure and the release of vasopressin from the pituitary. Recently it has been shown that systemically administered ANG II also reduces voluntary alcohol intake. The present study assessed the role of the SFO in alcohol consumption by examining the effects of SFO lesions on voluntary alcohol intake and on the suppression of voluntary alcohol intake by ANG II. Whereas the lesion did not alter alcohol consumption per se, it did significantly attenuate the ability of ANG II to reduce alcohol intake. This effect was not due to a lesion-induced change in the pharmacokinetics of alcohol and was observed only in those animals whose lesions produced a functional deficit, i.e., abolishing the increase in water drinking produced by ANG II. These results indicate that the SFO mediates the effect of systemically administered ANG II on alcohol intake but does not otherwise affect the regulation of alcohol consumption.
L A Grupp; E Perlanski; R B Stewart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  34     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-04-03     Completed Date:  1990-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-5     Citation Subset:  IM    
Department of Pharmacology, University of Toronto, Ontario, Canada.
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MeSH Terms
Alcohol Drinking / drug effects*,  physiology
Angiotensin II / pharmacology*,  physiology
Drinking Behavior / drug effects
Ethanol / blood
Neurosecretory Systems / physiology*
Rats, Inbred Strains
Renin-Angiotensin System
Subfornical Organ / physiology*
Reg. No./Substance:
11128-99-7/Angiotensin II; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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