Document Detail


Systemic alpha-interferon in multiple sclerosis. Long-term patient follow-up.
MedLine Citation:
PMID:  3800723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twelve patients with relapsing multiple sclerosis who had participated in a clinical trial of systemic (subcutaneous) natural alpha-interferon were interviewed and reexamined 4.3 years after beginning interferon treatment and 2.3 years after completion of the study. There was a progressive reduction in exacerbation rate from 1.33 per year to 0.47 per year. Overall neurologic function and disability did not change significantly. Six patients stabilized or improved, and were able to carry on normal daily activities. There were no long-term deleterious side effects. These results are similar to those described for patients treated with intrathecal beta-interferon. The mechanism of the prolonged beneficial effect is unknown, but is unlikely to represent antiviral activity in the central nervous system, and more probably involves systemic immunoregulatory functions. The systemic route of administration of interferon may be as effective as the intrathecal route in multiple sclerosis, and is potentially less hazardous.
Authors:
H S Panitch
Related Documents :
11003633 - Efficacy of long-term lamivudine monotherapy in patients with hepatitis b e antigen-neg...
24632673 - Recombinant human activated protein c in the treatment of acute respiratory distress sy...
12939213 - Benefits and risks of abciximab use in primary angioplasty for acute myocardial infarct...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of neurology     Volume:  44     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-01-27     Completed Date:  1987-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  61-3     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Double-Blind Method
Female
Follow-Up Studies
Humans
Interferon Type I / therapeutic use*
Male
Multiple Sclerosis / therapy*
Chemical
Reg. No./Substance:
0/Interferon Type I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The electroencephalogram in Alzheimer-type dementia. A sequential study correlating the electroencep...
Next Document:  The acquired immunodeficiency syndrome dementia complex as the presenting or sole manifestation of h...