Document Detail

Systemic administration of the adenosine A(2A) agonist CGS 21680 induces sedation at doses that suppress lever pressing and food intake.
MedLine Citation:
PMID:  18281083     Owner:  NLM     Status:  MEDLINE    
Adenosine A(2A) receptors are involved in the regulation of several behavioral functions. Adenosine A(2A) antagonists exert antiparkinsonian effects in animal models, and adenosine A(2A) agonists suppress locomotion and impair various aspects of motor control. The present experiments were conducted to study the effects of low doses of the adenosine A(2A) agonist CGS 21680 on lever pressing, specific parameters of food intake, and sedation. In the first experiment, the effects of CGS 21680 on fixed ratio 5 lever pressing were assessed. In the second experiment, rats were tested in 30 min feeding sessions, and also were observed for drug-induced sedation using a sedation rating scale. CGS 21680 (0.025, 0.05, 0.1 mg/kg IP) produced a dose related suppression of lever pressing, and also reduced the amount of food consumed. The feeding effect was largely dependent upon a slowing of the rate of feeding, and there was only a modest suppression of time spent feeding. Doses of CGS 21680 that suppressed lever pressing and feeding also were associated with sedation/drowsiness. In conjunction with other studies, the present results suggest that sedative effects may play an important role in some of the behavioral effects produced by systemic administration of adenosine A(2A) agonists.
Susana Mingote; Mariana Pereira; Andrew M Farrar; Peter J McLaughlin; John D Salamone
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-01-17
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  89     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-03-21     Completed Date:  2008-05-20     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  IM    
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MeSH Terms
Adenosine / analogs & derivatives*,  pharmacology
Adenosine A2 Receptor Agonists*
Conditioning, Operant / drug effects*
Dose-Response Relationship, Drug
Eating / drug effects*
Hypnotics and Sedatives / pharmacology*
Phenethylamines / pharmacology*
Rats, Sprague-Dawley
Grant Support
R01 MH078023/MH/NIMH NIH HHS; R01 MH078023-02/MH/NIMH NIH HHS
Reg. No./Substance:
0/Adenosine A2 Receptor Agonists; 0/Hypnotics and Sedatives; 0/Phenethylamines; 120225-54-9/2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; K72T3FS567/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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