Document Detail

Systemic administration of Met-enkephalin, (D-Ala2)-Met-enkephalin, beta-endorphin, and (D-Ala2)-beta-endorphin: effects on eating, drinking and activity measures in rats.
MedLine Citation:
PMID:  523499     Owner:  NLM     Status:  MEDLINE    
Rats were given four daily, interperitoneal injections (80 micrograms/kg) of Met-enkephalin, (D-Ala2)-Met-enkephalin-NH2, beta-endorphin, (D-Ala2)-beta-endorphin or the diluent (0.9% NaCl acidified to, 0.01 M with acetic acid). Animals were subsequently tested for food and water inake and activity. Met-enkephalin injections did not affect any of the measures but its (D-Ala2) analog reduced food intake and some of the activity measures in a complicated way. beta-Endorphin injections did not affect food or water intake; in familiar situations these animals were less active while novel situations seemed to potentiate activity. The (D-Ala2) analog reduced wheel running over 24 hours.
M G King; A J Kastin; R D Olson; D H Coy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  11     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  407-11     Citation Subset:  IM    
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MeSH Terms
Drinking Behavior / drug effects*
Emotions / drug effects
Endorphins / administration & dosage,  pharmacology*
Enkephalins / administration & dosage,  pharmacology*
Feeding Behavior / drug effects*
Injections, Intraperitoneal
Motor Activity / drug effects*
Reg. No./Substance:
0/Endorphins; 0/Enkephalins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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