| Systemic therapies in managing sinonasal inflammation. | |
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MedLine Citation:
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PMID: 20525510 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic rhinosinusitis (CRS) is a condition characterized by persistent inflammation due to intrinsic mucosal hypersensitivity or persistent infection. Proper medical treatment with antibiotic, leukotriene modifiers, oral corticosteroids, or even aspirin desensitization for the sinus inflammation can prevent the need for surgical intervention. The key to delineating the specific medical application is to determine the cause of the sinus mucosa dysfunction and its specific inflammatory pathway. Such targeted antiinflammatory medical therapy will lead to improved efficacy in the management of CRS. Even if surgical intervention is required, postoperative medical treatment is essential to minimizing the intrinsic mucosal inflammation and therefore preventing revision endoscopic procedures. |
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Authors:
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Michael A DeMarcantonio; Joseph K Han |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Otolaryngologic clinics of North America Volume: 43 ISSN: 1557-8259 ISO Abbreviation: Otolaryngol. Clin. North Am. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-07 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0144042 Medline TA: Otolaryngol Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 551-63, ix Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, 600 Gresham Drive, Suite 1100, Norfolk, VA 23507, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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therapeutic use Combined Modality Therapy Drug Therapy / methods* Eosinophils Histamine Antagonists / therapeutic use Humans Hydroxyurea / analogs & derivatives, therapeutic use Immunologic Factors / therapeutic use Leukotriene Antagonists / therapeutic use Otorhinolaryngologic Surgical Procedures / methods* Rhinitis / complications*, drug therapy*, surgery Sinusitis / complications*, drug therapy*, surgery Tosyl Compounds / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Histamine Antagonists; 0/Immunologic Factors; 0/Leukotriene Antagonists; 0/Tosyl Compounds; 107753-78-6/zafirlukast; 127-07-1/Hydroxyurea; 132880-11-6/zileuton |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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