Document Detail

Systemic lidocaine decreased the perioperative opioid analgesic requirements but failed to reduce discharge time after ambulatory surgery.
MedLine Citation:
PMID:  19923506     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In this randomized, blinded, placebo-controlled trial, we evaluated whether systemic lidocaine would reduce pain and time to discharge in ambulatory surgery patients. METHODS: Sixty-seven patients were enrolled to receive lidocaine or saline infusion perioperatively. RESULTS: Length of postanesthesia care unit (PACU) stay did not differ between groups. Intraoperative opioid use was significantly less in the lidocaine group, both in the PACU and during the total study period but not after discharge. In the PACU, patients in the lidocaine group reported less pain (visual analog scale score 3.1 +/- 2.04 vs 4.5 +/- 2.9; P = 0.043). There were no differences in postoperative nausea and vomiting. CONCLUSION: Perioperative systemic lidocaine significantly reduces opioid requirements in the ambulatory setting without affecting time to discharge.
Allannah McKay; Antje Gottschalk; Annette Ploppa; Marcel E Durieux; Danja S Groves
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  109     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2009-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1805-8     Citation Subset:  AIM; IM    
Department of Anesthesia, University of Virginia, Charlottesville, VA 22908-0710, USA.
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MeSH Terms
Ambulatory Surgical Procedures*
Analgesics, Opioid / adverse effects,  therapeutic use*
Anesthesia Recovery Period*
Anesthetics, Local / administration & dosage*,  adverse effects
Double-Blind Method
Infusions, Intravenous
Length of Stay
Lidocaine / administration & dosage*,  adverse effects
Middle Aged
Pain Measurement
Pain, Postoperative / prevention & control*
Patient Discharge*
Postoperative Nausea and Vomiting / etiology
Time Factors
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Local; 137-58-6/Lidocaine
Comment In:
Anesth Analg. 2009 Dec;109(6):1718-9   [PMID:  19923494 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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