Document Detail

Systemic inflammation, intraventricular hemorrhage, and white matter injury.
MedLine Citation:
PMID:  23112243     Owner:  NLM     Status:  MEDLINE    
To see if the systemic inflammation profile of 123 infants born before the 28th week of gestation who had intraventricular hemorrhage without white matter injury differed from that of 68 peers who had both lesions, we compared both groups to 677 peers who had neither. Cranial ultrasound scans were read independently by multiple readers until concordance. The concentrations of 25 proteins were measured with multiplex arrays using an electrochemiluminescence system. Infants who had both hemorrhage and white matter injury were more likely than others to have elevated concentrations of C-reactive protein and interleukin 8 on days 1, 7, and 14, and elevated concentrations of serum amyloid A and tumor necrosis factor-α on 2 of these days. Intraventricular hemorrhage should probably be viewed as 2 entities: hemorrhage alone and hemorrhage with white matter injury. Each entity is associated with inflammation, but the combination has a stronger inflammatory signal than hemorrhage alone.
Alan Leviton; Elizabeth N Allred; Olaf Dammann; Stephen Engelke; Raina N Fichorova; Deborah Hirtz; Karl C K Kuban; Laura R Ment; T Michael O'shea; Nigel Paneth; Bhavesh Shah; Michael D Schreiber;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-30
Journal Detail:
Title:  Journal of child neurology     Volume:  28     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-11-14     Completed Date:  2014-06-30     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1637-45     Citation Subset:  IM    
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MeSH Terms
Age Factors
C-Reactive Protein / metabolism
Cerebral Hemorrhage / etiology*,  ultrasonography
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / physiopathology*,  ultrasonography
Inflammation / etiology*,  ultrasonography
Interleukin-8 / metabolism
Leukoencephalopathies / etiology*,  ultrasonography
Odds Ratio
Serum Amyloid A Protein
Tumor Necrosis Factor-alpha / metabolism
Ultrasonography, Doppler
Grant Support
5P30HD018655-28/HD/NICHD NIH HHS; 5U01NS040069-05/NS/NINDS NIH HHS; P30 HD018655/HD/NICHD NIH HHS; U01 NS040069/NS/NINDS NIH HHS
Reg. No./Substance:
0/Interleukin-8; 0/Serum Amyloid A Protein; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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