Document Detail


Systemic Candida infection in University hospital 1997-1999: the distribution of Candida biotypes and antifungal susceptibility patterns.
MedLine Citation:
PMID:  11307597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 102 Candida species were isolated from blood cultures from January 1997 to October 1999. Using assimilation of carbohydrate test, 52 (51.0%) of the Candida sp. were identified as C. parapsilosis, 25.5% (26) were C. tropicalis. C. albicans made up 11.8% (12), 6.9% (7) were C. rugosa, 3.8% (4) C. glabrata and 1% (1) C. guilliermondii. No C. dubliniensis was found in the study. In vitro antifungal susceptibility tests showed that all Candida species were sensitive to nystatin, amphotericin B and ketoconazole. Although all isolates remained sensitive to fluconazole, intermediate susceptibility was found in 3 C. rugosa isolates. Antifungal agents with high frequency of resistance were econazole, clotrimazole, miconazole and 5-fluorocytosine. Candida species found to have resistance to these antifungal agents were non-C. albicans.
Authors:
K P Ng; T L Saw; S L Na; T S Soo-Hoo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mycopathologia     Volume:  149     ISSN:  0301-486X     ISO Abbreviation:  Mycopathologia     Publication Date:  2001  
Date Detail:
Created Date:  2001-04-18     Completed Date:  2001-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505689     Medline TA:  Mycopathologia     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. kpng@medicine.med.um.edu.my
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / pharmacology*
Candida / classification*,  drug effects,  metabolism
Candidiasis / blood,  drug therapy,  microbiology*
Carbohydrate Metabolism
Cross Infection / blood,  drug therapy,  microbiology*
Drug Resistance, Microbial
Hospitals, University
Humans
Microbial Sensitivity Tests
Chemical
Reg. No./Substance:
0/Antifungal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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