Document Detail

Systemic arterial pressure at maturity in rats following chronic hypoxia in early life.
MedLine Citation:
PMID:  20671717     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effect of prolonged hypoxemia in early life on systemic arterial blood pressure at maturity was assessed in Sprague-Dawley rats.
METHODS: Animals hypoxic in early life (12 males, 10 females) were raised in hypoxia (FiO₂ = 0.12) for the first 10 days of life and subsequently raised in normoxia, along with age-matched controls (11 males, 9 females). At 2 months of age, arterial blood pressure was recorded intravascularly using telemetry in awake and unrestrained animals over two 12-h night-time (active) and daytime (resting) periods. Aortic pulse wave velocity was assessed in six additional hypoxic pretreated and five control anesthetized 2-month-old male rats.
RESULTS: Systolic, mean, and pulse pressures were significantly greater in the hypoxic pretreated group compared to the control group during resting and active periods in both sexes (P ≤ 0.05). Diastolic pressure and heart rate did not differ between the two groups. Hypoxic pretreated males displayed significantly increased blood pressure variability during the resting period. Aortic pulse wave velocity was also found to be elevated in the hypoxic pretreated rats.
CONCLUSIONS: Prolonged hypoxic stress in early life in the rat is associated with increased systolic arterial pressure at maturity very likely due to decreased arterial compliance. These findings suggest that a nutrient-independent, postnatal stress may lead to long-lasting vascular alterations predisposing to increased arterial pressure at maturity. This raises the possibility that adult survivors of congenital cyanotic cardiac disease may be at risk for secondary cardiovascular morbidity unrelated to surgical repair or residual cardiac defects.
Bryan Ross; Matthew McIntosh; Demetra Rodaros; Terence E Hébert; Charles V Rohlicek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-29
Journal Detail:
Title:  American journal of hypertension     Volume:  23     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2011-01-31     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1228-33     Citation Subset:  IM    
Department of Physiology, McGill University, Montréal, Quebec, Canada.
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MeSH Terms
Age Factors
Anoxia / epidemiology*,  physiopathology*
Blood Flow Velocity / physiology
Blood Pressure / physiology*
Body Weight / physiology
Caloric Restriction
Chronic Disease
Compliance / physiology
Cyanosis / epidemiology,  physiopathology
Heart Defects, Congenital / epidemiology,  physiopathology
Heart Rate / physiology
Hypertension / epidemiology*,  physiopathology*
Pulsatile Flow / physiology
Rats, Sprague-Dawley
Risk Factors
Stress, Physiological / physiology*
Grant Support
//Canadian Institutes of Health Research
Comment In:
Am J Hypertens. 2010 Nov;23(11):1158   [PMID:  20956963 ]

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