Document Detail

[Systematic reviews and metaanalyses. Basic knowledge, strengths and weaknesses of an important tool for healthcare professionals].
MedLine Citation:
PMID:  20665362     Owner:  NLM     Status:  MEDLINE    
Once rather a niche business, evidence-based medicine (EBM) as an approach to clinical decision-making requiring the integration of the best available research evidence with individual clinical expertise and patient values, has gained widespread acceptance and support within the healthcare community. This review article covers the basic principles of systematic reviews and meta-analyses, and their role in the process of evidence-based decision-making. The strengths and weaknesses of traditional narrative reviews are discussed, as well as the way systematic reviews limit bias associated with the assembly, critical appraisal and synthesis of studies addressing specific clinical questions. The authors provide a step-by-step introduction for the most relevant issues in writing a systematic review from the initial formulation of a research question according to the PICO-rule to sensitivity analyses in conjunction with the combined analysis of the pooled data. Special emphasis is put on important issues that need to be considered when appraising a systematic review or meta-analysis, thus providing a description on how to use systematic reviews for clinical decision-making. Some of the terms that are frequently used in the reporting of systematic reviews and meta-analyses, such as relative risk, confidence interval, Forest plot or L'Abbé plot, will be introduced and explained.
Alexander Schnabel; Peter Kranke
Publication Detail:
Type:  English Abstract; Journal Article; Review     Date:  2010-07-21
Journal Detail:
Title:  Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS     Volume:  45     ISSN:  1439-1074     ISO Abbreviation:  Anasthesiol Intensivmed Notfallmed Schmerzther     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109478     Medline TA:  Anasthesiol Intensivmed Notfallmed Schmerzther     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  510-8     Citation Subset:  IM    
Copyright Information:
(c) Georg Thieme Verlag Stuttgart-New York.
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikums Münster.
Vernacular Title:
Systematische Ubersichtsarbeiten und Metaanalysen. Erstellung, Bedeutung und Interpretation.
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MeSH Terms
Clinical Trials as Topic
Data Interpretation, Statistical
Evidence-Based Medicine / methods,  trends*
Information Storage and Retrieval
Meta-Analysis as Topic*
Quality Control
Research Design / standards
Review Literature as Topic

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